Although there has been little research examining religiosity in athletes, recent evidence suggests that it may play an important role in the lives of some athletes. The present study investigated the relationship of intrinsic religiosity to substance use in intercollegiate athletes. The Intrinsic Religiosity subscale of the Duke Religion Index, the Alcohol Problems subscale of the Personality Assessment Inventory, and two questions assessing marijuana and other drug use were completed by 105 varsity athletes. Findings indicated that intrinsic religiosity was inversely associated with alcohol, marijuana, and other drug use. Implications of these findings for sport practitioners are discussed.