Biological Changes Induced by Physical Activity in Individuals with Down’s Syndrome

in Adapted Physical Activity Quarterly

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Yves EberhardUniversité Joseph Fourier

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Jacqueline EterradossiUniversité Joseph Fourier

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Bettina DebûUniversité Joseph Fourier

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The effects of exercise and of a physical conditioning program on 11 subjects (7 males, 4 females, aged 15 to 20) with Down’s syndrome (DS) were analyzed. Metabolic responses were evaluated before and after two ergometric cycle exercise tests: an incremental exercise to symptom limited VO2 max. and an endurance test performed at 60% of maximal aerobic power. Plasma substrates, electrolytes, catecholamines, lipoprotein lipid profiles, and superoxide dismutase were assayed immediately before and after these tests. The results indicated (a) a low blood lactate level for peak exercise, (b) slow free fatty acid mobilization at the start of exercise, (c) a low level of cholesterol HDL and a high level of pre-beta VLDL at rest, (d) adjustment to nearly normal lipid profiles with endurance activity, and (e) differences between before and after training for superoxide dismutase levels in subjects with DS. These results suggest that endurance training could have long-term effects on the pathophysiological consequences of DS.

The authors express sincere appreciation to adolescents with DS and adults at the Institut Médico Educatif Les Nivéoles in Voiron; at the Institut Médico Educatif Henri Daudignon in Grenoble; at the Centre d’Aide par le Travail and the Foyer La Revériaz in Chambéry; their educators; parents of the Association de Recherche pour l’Insertion Sociale des Trisomiques 21 (ARIST); staff of laboratory in Sport Medicine; laboratory of Biochemistry A at Albert Michallon Hospital of Grenoble; and the Scientific Council of Université Joseph Fourier of Grenoble for their participation and support.

Yves Eberhard and Bettina Debû both are with the Laboratoire Resact-Sport and Jacqueline Eterradossi is with the Service de Biologie et de Médecine du Sport, all at the Université Joseph Fourier, Grenoble, France.

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