The subjects were 170 moderately and severely mentally retarded men who were divided into two groups. The first group was used to formulate a new prediction equation and the second group was used to cross-validate and ascertain the stability of the derived equation. The prediction equation, employing waist and forearm circumferences, height and weight as predictors, and estimated percent body fat calculated by the generalized regression equation of Jackson and Pollock (1978) as the criterion measure, was formulated using a stepwise multiple regression analysis. A multiple R value of .86 was obtained for the derived equation with a standard error of estimate value of 3.35. The equation was cross-validated on the second sample to ascertain its stability. An r of .81 and a standard error of estimate of 4.41 was obtained between the subjects’ estimated percent body fat, using the new equation, and the criterion measure. This simplified equation provides practitioners with an accurate, reliable, and inexpensive method of estimating percent body fat for adult mentally retarded males.