Clinical Question: Is there evidence to support that Kinesio Tape is more effective in decreasing kinesiophobia than placebo taping in patients with musculoskeletal pain? Clinical Bottom Line: There is currently inconsistent, high-quality evidence demonstrating that the application of Kinesio Tape may decrease kinesiophobia in patients with musculoskeletal pain. Future research should examine the effects of Kinesio Tape on kinesiophobia in patients with musculoskeletal pain.