Several investigators have aimed to predict recurrent injuries following acute ankle sprains, but none has done so in high school or collegiate athletes. The purpose of this study was to determine the ability of demographic, anthropometric, and disease- and patient-oriented outcomes to predict recurrent ankle sprains in athletes during the same competitive season following return to play from an ankle sprain. Only increased patient height and mass were associated with increased odds of sustaining a recurrent ankle sprain. Thus, taller and heavier patients might have the greatest risk of sustaining a recurrent ankle sprain in the same season as a previous ankle sprain.