Clinical Scenario: Athletic trainers should be aware of how physical activity may influence the risk of nocturnal hypoglycemia in adolescents with type 1 diabetes (T1D). Clinical Question: Does the timing and intensity of physical activity affect the occurrence and risk of nocturnal hypoglycemia in adolescents with T1D? Results of the Search: Four studies meeting the inclusion criteria were found and included in the appraisal. Three studies were prospective observational cohorts, and one was a randomized case-crossover study. Clinical Bottom Line: Adolescents with T1D may be at greater risk of nocturnal hypoglycemia after performing 30–60 minutes of moderate-to-vigorous physical activity during the late afternoon or evening. Implications: Athletic trainers should educate adolescents with T1D and their parents about the risk of nocturnal hypoglycemia after MVPA, and work in collaboration with the diabetes care physician to ensure prevention techniques are included in the patient'’s diabetes care plan. Level of Evidence: Strength of Recommendation Taxonomy Grade B.