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W.R. Frontera and L.S. Krivickas are with the Department of Physical Medicine and Rehabilitation at Harvard Medical School and Spaulding Rehabilitation Hospital, Boston, MA 02114. V.A. Hughes, R. Roubenoff, and Frontera are with the Nutrition, Exercise Physiology, and Sarcopenia Laboratory at the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA.