This study examined the effects of a pre-exercise meal and a carbohydrate-electrolyte solution on endurance running capacity. Ten men performed 3 treadmill runs at 70% V̇O_2max to exhaustion after consuming (a) a carbohydrate meal 3 h before exercise and a carbohydrate-electrolyte solution during exercise (M+C); or (b) the carbohydrate meal 3 h before exercise and water during exercise (M+W): or (c) a liquid placebo 3 h before exercise and water during exercise (P+W). Exercise time was longer in M+C (125.1 ±5.3 min; mean±SE) and M+W (111.9 ± 5.6 min) compared with P+W (102.9 ± 7.9 min;p< .01 and p < .05, respectively), and longer in M+C compared with M+W (p < .05). Serum insulin concentration at the start of exercise and carbohydrate oxidation rates during the first hour of exercise were higher, whereas plasma FFA concentrations throughout exercise were lower in M+W and M+C than in P+W (p < .01). A carbohydrate meal before exercise at 70% V̇O_2max improved endurance running capacity; however, me combination of the meal and a carbohydrate-electrolyte solution during exercise further improved endurance running capacity.