Influence of Carbohydrate Ingestion on Cytokine Responses Following Acute Resistance Exercise

in International Journal of Sport Nutrition and Exercise Metabolism
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The effect of carbohydrate supplementation (CHO) on interleukin 2 (IL-2) and interleukin 5 (IL-5) secretion following acute resistance exercise was examined in 9 resistance-trained males. Subjects completed a randomized, double-blind protocol with exercise separated by 14 days. The exercise consisted of a high intensity, short rest interval squat workout. Subjects consumed 1.0 g · kg body mass-1 CHO or an equal volume of placebo (PLC) 10 min prior to and 10 min following exercise. Blood was collected at rest (REST), immediately post exercise (POST), and at 1.5 h of recovery (1.5 h POST). Isolated peripheral blood mononuclear cells were stimulated with PHA and assayed for IL-2 and IL-5 secretion. IL-2 secretion was significantly decreased at POST for both the PLC and CHO groups. However, the degree of decrease was less in the CHO group (16%) than in the PLC group (48%), and this difference was statistically significant. These responses were transient, and the values returned to normal by 1.5 h POST. A mild and transient but significant decrease in IL-5 secretion by the PLC group was observed at POST (26%) compared to REST. No significant decrease was observed in IL-5 secretion for CHO from REST to POST (12%). These data support a possible effect of carbohydrate supplementation on IL-2 and IL-5 secretion following high-intensity resistance exercise.

M.A. Chan is with Science and Technology, AAI-International, 12400 Shawnee Mission Parkway, Shawnee, KS 66216. A.J. Koch is with the Division of Health and Exercise Sciences at Truman State University, Kirksville, MO 63501. S.H. Benedict is with the Department of Molecular Biosciences at the University of Kansas, Lawrence, KS 66045. J.A. Potteiger is with the Department of Physical Education, Health and Sport Studies at Miami University, Oxford, OH 45056-3491.