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This study assessed the effects of resistive training (RT) with or without chromium picolinate (Cr-pic) supplementation on the 24-h urinary excretions of myo-inositol, D-chiro-inositol, and pinitol, as well as clinical indices of kidney and liver functions. Thirty-two nondiabetic subjects, age 62 ± 4 y, performed RT twice weekly for 12 wk and consumed either 924 μg Cr/d as Cr-pic (n = 17) or a placebo (n = 15). Whole-body strength increased in all subjects by 20% and urinary chromium excretion increased 47-fold in the Cr-pic group. Urinary myo-inositol, D-chiro-inositol, and pinitol were not changed with RT or influenced by Cr-pic. Serum indices of kidney and liver functions were within clinically normal ranges at baseline and the end of the study. These results suggest that RT did not influence the urinary excretions of inositols. High dose Cr-pic did not influence the urinary excretion of inositols and the selected indices of kidney and liver functions in conjunction with RT
W.W. Campbell is with the Dept of Foods and Nutrition. Purdue University. West Lafayette, IN 47907. L.J.O. Joseph is with the Division of Gerontology, Dept of Medicine, and GRECC at the University of Maryland at Baltimore, Baltimore, MD 21201. R.A. Farrell is with the Dept of Exercise and Sport Science. East Carolina University. Greenville. NC 27858. R.E. Ostlund, Jr. is with the Dept of Medicine at Washington University, Si. Louis, MO 63110. R.A. Anderson is with the USDA Beltsville Human Nutrition Research Center. Beltsviile. MD 20705. W.J. Evans is with the Nutrition. Metabolism and Exercise Program in the Reynolds Dept of Geriatrics and GRECC at the University of Arkansas for Medical Sciences. Little Rock, AR 72205.