Effects of an Alleged Myostatin-Binding Supplement and Heavy Resistance Training on Serum Myostatin, Muscle Strength and Mass, and Body Composition

in International Journal of Sport Nutrition and Exercise Metabolism
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This study examined 12 wk of resistance training and cystoseim canariensis supplementation on serum levels of myostatin and follistatin-like related gene (FLRG) and muscle strength and body composition. Twenty-two untrained males were randomly assigned to a placebo (PLC) or myostatin binder (MYO) group in a double-blind fashion. Blood was obtained before and after 6 and 12 wk of training. PLC and MYO trained thrice weekly using 3 sets of 6 to 8 repetitions at 85% to 90% 1 repetition maximum. MYO ingested 1200 mg/d of cystoseim canariensis. Data were analyzed with 2-way ANOVA. After training, total body mass, fat-free mass, muscle strength, thigh volume/mass, and serum myostatin and FLRG increased for both groups (P < 0.05); however, there were no differences between groups (P > 0.05). Twelve wk of heavy resistance training and 1200 mg/d of cystoseim canariensis supplementation appears ineffective at inhibiting serum myostatin and increasing muscle strength and mass or decreasing fat mass.

The author is with the Exercise and Biochemical Nutrition Laboratory, Dept of Health, Human Performance, and Recreation, Baylor University, Waco, TX 76798-7313.

International Journal of Sport Nutrition and Exercise Metabolism
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