This study examined the effects of an aromatase-inhibiting nutritional supplement on serum steroid hormones, body composition, and clinical safety markers. Sixteen eugonadal young men ingested either Novedex XT™ or a placebo daily for 8 wk, followed by a 3-wk washout period. Body composition was assessed and blood and urine samples obtained at weeks 0, 4, 8, and 11. Data were analyzed by 2-way repeated-measures ANOVA. Novedex XT resulted in average increases of 283%, 625%, 566%, and 438% for total testosterone (P = 0.001), free testosterone (P = 0.001), dihydrotestosterone (P = 0.001), and the testosterone:estrogen ratio (P = 0.001), respectively, whereas fat mass decreased 3.5% (P = 0.026) during supplementation. No significant differences were observed in blood and urinary clinical safety markers or for any of the other serum hormones (P > 0.05). This study indicates that Novedex XT significantly increases serum androgen levels and decreases fat mass.
The authors are with the Dept. of Health, Human Performance, and Recreation, Baylor University, Waco, TX 76798-7313.