The Effects of Caffeine Mouth Rinsing on Exercise Performance: A Systematic Review

in International Journal of Sport Nutrition and Exercise Metabolism
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Caffeine ingestion can improve performance across a variety of exercise modalities but can also elicit negative side effects in some individuals. Thus, there is a growing interest in the use of caffeine mouth rinse solutions to improve sport and exercise performance while minimizing caffeine’s potentially adverse effects. Mouth rinse protocols involve swilling a solution within the oral cavity for a short time (e.g., 5–10 s) before expectorating it to avoid systemic absorption. This is believed to improve performance via activation of taste receptors and stimulation of the central nervous system. Although reviews of the literature indicate that carbohydrate mouth rinsing can improve exercise performance in some situations, there has been no attempt to systematically review the available literature on caffeine mouth rinsing and its effects on exercise performance. To fill this gap, a systematic literature search of three databases (PubMed, SPORTDiscus, and Web of Science) was conducted by two independent reviewers. The search resulted in 11 randomized crossover studies that were appraised and reviewed. Three studies found significant positive effects of caffeine mouth rinsing on exercise performance, whereas the remaining eight found no improvements or only suggestive benefits. The mixed results may be due to heterogeneity in the methods across studies, interindividual differences in bitter tasting, and differences in the concentrations of caffeine solutions. Future studies should evaluate how manipulating the concentration of caffeine solutions, habitual caffeine intake, and genetic modifiers of bitter taste influence the efficacy of caffeine mouth rinsing as an ergogenic strategy.

The authors are with the Department of Human Movement Sciences, Old Dominion University, Norfolk, VA, USA.

Ehlert (aehle003@odu.edu) is corresponding author.
  • Ali, A., O’Donnell, J.M., Starck, C., & Rutherfurd-Markwick, K.J. (2015). The effect of caffeine ingestion during evening exercise on subsequent sleep quality in females. International Journal of Sports Medicine, 36(6), 433439. doi:10.1055/s-0034-1398580

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Beaven, C.M., Maulder, P., Pooley, A., Kilduff, L., & Cook, C. (2013). Effects of caffeine and carbohydrate mouth rinses on repeated sprint performance. Applied Physiology, Nutrition, and Metabolism, 38(6), 633637. PubMed ID: 23724880 doi:10.1139/apnm-2012-0333

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Beedie, C.J., Stuart, E.M., Coleman, D.A., & Foad, A.J. (2006). Placebo effects of caffeine on cycling performance. Medicine & Science in Sports & Exercise, 38(12), 2159. PubMed ID: 17146324 doi:10.1249/01.mss.0000233805.56315.a9

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Behrens, M., & Meyerhof, W. (2013, March). Bitter taste receptor research comes of age: From characterization to modulation of TAS2Rs. Seminars in cell & developmental biology, 24(3), 215221. doi:10.1016/j.semcdb.2012.08.006

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Blanchard, J., & Sawers, S.J.A. (1983). The absolute bioavailability of caffeine in man. European Journal of Clinical Pharmacology, 24(1), 9398. PubMed ID: 6832208 doi:10.1007/BF00613933

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Bottoms, L., Hurst, H., Scriven, A., Lynch, F., Bolton, J., Vercoe, L., . . . Sinclair, J. (2014). The effect of caffeine mouth rinse on self-paced cycling performance. Comparative Exercise Physiology, 10(4), 239245. doi:10.3920/CEP140015

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Boyett, J.C., Giersch, G.E., Womack, C.J., Saunders, M.J., Hughey, C.A., Daley, H.M., & Luden, N.D. (2016). Time of day and training status both impact the efficacy of caffeine for short duration cycling performance. Nutrients, 8(10), 639. doi:10.3390/nu8100639

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Brietzke, C., Franco-Alvarenga, P.E., Coelho-Júnior, H.J., Silveira, R., Asano, R.Y., & Pires, F.O. (2019). Effects of carbohydrate mouth rinse on cycling time trial performance: A systematic review and meta-analysis. Sports Medicine, 49(1), 5766. PubMed ID: 30488186 doi:10.1007/s40279-018-1029-7

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Chambers, E.S., Bridge, M.W., & Jones, D.A. (2009). Carbohydrate sensing in the human mouth: Effects on exercise performance and brain activity. The Journal of Physiology, 587(8), 17791794. doi:10.1113/jphysiol.2008.164285

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Chan, E.Y., & Maglio, S.J. (2019). Coffee cues elevate arousal and reduce level of construal. Consciousness and Cognition, 70, 5769. PubMed ID: 30849742 doi:10.1016/j.concog.2019.02.007

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Clarke, N.D., Kornilios, E., & Richardson, D.L. (2015). Carbohydrate and caffeine mouth rinses do not affect maximum strength and muscular endurance performance. Journal of Strength and Conditioning Research, 29(10), 29262931. PubMed ID: 25785703 doi:10.1519/JSC.0000000000000945

    • Crossref
    • Search Google Scholar
    • Export Citation
  • De Ataide e Silva, T., Di Cavalcanti Alves de Souza, M., De Amorim, J.F., Stathis, C.G., Leandro, C.G., & Lima-Silva, A.E. (2014). Can carbohydrate mouth rinse improve performance during exercise? A systematic review. Nutrients, 6(1), 110. doi:10.3390/nu6010001

    • Crossref
    • Search Google Scholar
    • Export Citation
  • de Morton, N.A. (2009). The PEDro scale is a valid measure of the methodological quality of clinical trials: A demographic study. Australian Journal of Physiotherapy, 55(2), 129133. PubMed ID: 19463084 doi:10.1016/S0004-9514(09)70043-1

    • Crossref
    • Search Google Scholar
    • Export Citation
  • De Pauw, K., Roelands, B., Knaepen, K., Polfliet, M., Stiens, J., & Meeusen, R. (2015). Effects of caffeine and maltodextrin mouth rinsing on P300, brain imaging, and cognitive performance. Journal of Applied Physiology, 118(6), 776782. doi:10.1152/japplphysiol.01050.2014

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Doering, T.M., Fell, J.W., Leveritt, M.D., Desbrow, B., & Shing, C.M. (2014). The effect of a caffeinated mouth-rinse on endurance cycling time-trial performance. International Journal of Sport Nutrition and Exercise Metabolism, 24(1), 9097. PubMed ID: 23980239 doi:10.1123/ijsnem.2013-0103

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Dolan, P., Witherbee, K.E., Peterson, K.M., & Kerksick, C.M. (2017). Effect of carbohydrate, caffeine, and carbohydrate + caffeine mouth rinsing on intermittent running performance in collegiate male lacrosse athletes. Journal of Strength and Conditioning Research, 31(9), 24732479. PubMed ID: 28825605 doi:10.1519/JSC.0000000000001819

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Duffy, V.B., Davidson, A.C., Kidd, J.R., Kidd, K.K., Speed, W.C., Pakstis, A.J., . . . Bartoshuk, L.M. (2004). Bitter receptor gene (TAS2R38), 6-n-propylthiouracil (PROP) bitterness and alcohol intake. Alcoholism: Clinical and Experimental Research, 28(11), 16291637. doi:10.1097/01.ALC.0000145789.55183.D4

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Fukuda, M. (2019). Habitual coffee drinkers may present conditioned responses from coffee-cue. Current psychology. doi:10.1007/s12144-019-00542-0.

    • Search Google Scholar
    • Export Citation
  • Gam, S., Guelfi, K.J., & Fournier, P.A. (2014). Mouth rinsing and ingesting a bitter solution improves sprint cycling performance. Medicine & Science in Sports & Exercise, 46(8), 16481657. PubMed ID: 24504430 doi:10.1249/MSS.0000000000000271

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Gam, S., Guelfi, K.J., & Fournier, P.A. (2016). New insights into enhancing maximal exercise performance through the use of a bitter tastant. Sports Medicine, 46(10), 13851390. PubMed ID: 27000831 doi:10.1007/s40279-016-0522-0

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Gam, S., Tan, M., Guelfi, K.J., & Fournier, P.A. (2015). Mouth rinsing with a bitter solution without ingestion does not improve sprint cycling performance. European Journal of Applied Physiology, 115(1), 129138. PubMed ID: 25236837 doi:10.1007/s00421-014-2987-6

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Goldstein, E.R., Ziegenfuss, T., Kalman, D., Kreider, R., Campbell, B., Wilborn, C., . . . Wildman, R. (2010). International society of sports nutrition position stand: Caffeine and performance. Journal of the International Society of Sports Nutrition, 7(1), 5. PubMed ID: 20205813 doi:10.1186/1550-2783-7-5

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Graham, T.E. (2001). Caffeine and exercise. Sports Medicine, 31(11), 785807. PubMed ID: 11583104 doi:10.2165/00007256-200131110-00002

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Grgic, J., Grgic, I., Pickering, C., Schoenfeld, B.J., Bishop, D.J., & Pedisic, Z. (2020). Wake up and smell the coffee: Caffeine supplementation and exercise performance—An umbrella review of 21 published meta-analyses. British Journal of Sports Medicine, 54(11), 681688. PubMed ID: 30926628 doi:10.1136/bjsports-2018-100278

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Haase, L., Cerf-Ducastel, B., & Murphy, C. (2009). Cortical activation in response to pure taste stimuli during the physiological states of hunger and satiety. Neuroimage, 44(3), 10081021. PubMed ID: 19007893 doi:10.1016/j.neuroimage.2008.09.044

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Hagger, M.S., & Chatzisarantis, N.L. (2013). The sweet taste of success: The presence of glucose in the oral cavity moderates the depletion of self-control resources. Personality and Social Psychology Bulletin, 39(1), 2842. PubMed ID: 22995892 doi:10.1177/0146167212459912

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Kamimori, G.H., Karyekar, C.S., Otterstetter, R., Cox, D.S., Balkin, T.J., Belenky, G.L., & Eddington, N.D. (2002). The rate of absorption and relative bioavailability of caffeine administered in chewing gum versus capsules to normal healthy volunteers. International Journal of Pharmaceutics, 234(1–2), 159167. PubMed ID: 11839447 doi:10.1016/S0378-5173(01)00958-9

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Kaplan, A.R., Glanville, E.V., & Fischer, R. (1964). Taste thresholds for bitterness and cigarette smoking. Nature, 202(4939), 13661366. doi:10.1038/2021366a0

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Karayigit, R., Yasli, B.Ç., Karabiyik, H., Mitat, K.O.Z., & Ersoz, G. (2017). Effect of serial caffeine mouth rinse on Wingate anaerobic performance. Sportmetre Beden Eğitimi ve Spor Bilimleri Dergisi, 15(4), 191196.

    • Search Google Scholar
    • Export Citation
  • Kizzi, J., Sum, A., Houston, F.E., & Hayes, L.D. (2016). Influence of a caffeine mouth rinse on sprint cycling following glycogen depletion. European Journal of Sport Science, 16(8), 10871094. PubMed ID: 27686403 doi:10.1080/17461391.2016.1165739

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Lane, S.C., Bird, S.R., Burke, L.M., & Hawley, J.A. (2013). Effect of a carbohydrate mouth rinse on simulated cycling time-trial performance commenced in a fed or fasted state. Applied Physiology, Nutrition, and Metabolism, 38(2), 134139. PubMed ID: 23438223 doi:10.1139/apnm-2012-0300

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Leach, E.J., & Noble, A.C. (1986). Comparison of bitterness of caffeine and quinine by a time–intensity procedure. Chemical Senses, 11(3), 339345. doi:10.1093/chemse/11.3.339

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Marinho, A.H., Mendes, E.V., Vilela, R.A., Bastos-Silva, V.J., & Balikian, P. (2019). Caffeine mouth rinse has no effects on anaerobic energy yield during a Wingate test. Journal of Sports Medicine and Physical Fitness, 60(1), 6974. PubMed ID: 31640317

    • Search Google Scholar
    • Export Citation
  • Matsumoto, I. (2013). Gustatory neural pathways revealed by genetic tracing from taste receptor cells. Bioscience, Biotechnology, and Biochemistry, 77(7), 13591362. PubMed ID: 23832339 doi:10.1271/bbb.130117

    • Crossref
    • Search Google Scholar
    • Export Citation
  • McLellan, T.M., Caldwell, J.A., & Lieberman, H.R. (2016). A review of caffeine’s effects on cognitive, physical and occupational performance. Neuroscience & Biobehavioral Reviews, 71, 294312. PubMed ID: 27612937 doi:10.1016/j.neubiorev.2016.09.001

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Meeusen, R., Roelands, B., & Spriet, L.L. (2013). Caffeine, exercise and the brain. In L.J.C. van Loon, & R. Meeusen (Eds.), Limits of human endurance (Vol. 76, pp. 112). Basel, Switzerland: Karger Publishers.

    • Search Google Scholar
    • Export Citation
  • Mennella, J.A., Pepino, M.Y., Duke, F.F., & Reed, D.R. (2010). Age modifies the genotype-phenotype relationship for the bitter receptor TAS2R38. BMC Genetics, 11(1), 60. doi:10.1186/1471-2156-11-60

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Meyerhof, W., Batram, C., Kuhn, C., Brockhoff, A., Chudoba, E., Bufe, B., . . . Behrens, M. (2010). The molecular receptive ranges of human TAS2R bitter taste receptors. Chemical Senses, 35(2), 157170. PubMed ID: 20022913 doi:10.1093/chemse/bjp092

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Moher, D., Shamseer, L., Clarke, M., Ghersi, D., Liberati, A., Petticrew, M., . . . Stewart, L.A. (2015). Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Systematic Reviews, 4(1), 1. doi:10.1186/2046-4053-4-1

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Mora-Rodríguez, R., Pallarés, J.G., López-Gullón, J.M., López-Samanes, Á., Fernández-Elías, V.E., & Ortega, J.F. (2015). Improvements on neuromuscular performance with caffeine ingestion depend on the time-of-day. Journal of Science and Medicine in Sport, 18(3), 338342. doi:10.1016/j.jsams.2014.04.010

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Mora-Rodríguez, R., Pallarés, J.G., López-Samanes, Á., Ortega, J.F., & Fernández-Elías, V.E. (2012). Caffeine ingestion reverses the circadian rhythm effects on neuromuscular performance in highly resistance-trained men. PLoS One, 7(4). e33807. doi:10.1371/journal.pone.0033807

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Mumford, G.K., Benowitz, N.L., Evans, S.M., Kaminski, B.J., Preston, K.L., Sannerud, C.A., . . . Griffiths, R.R. (1996). Absorption rate of methylxanthines following capsules, cola and chocolate. European Journal of Clinical Pharmacology, 51(3–4), 319325. PubMed ID: 9010706 doi:10.1007/s002280050205

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Pallarés, J.G., Fernandez-Elias, V.E., Ortega, J.F., Munoz, G., Munoz-Guerra, J., & Mora-Rodriguez, R. (2013). Neuromuscular responses to incremental caffeine doses: Performance and side effects. Medicine & Science in Sports & Exercise, 45(11), 21842192. PubMed ID: 23669879 doi:10.1249/MSS.0b013e31829a6672

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Pallarés, J.G., López-Samanes, Á., Moreno, J., Fernández-Elías, V.E., Ortega, J.F., & Mora-Rodríguez, R. (2014). Circadian rhythm effects on neuromuscular and sprint swimming performance. Biological Rhythm Research, 45(1), 5160. doi:10.1080/09291016.2013.797160

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Pataky, M.W., Womack, C.J., Saunders, M.J., Goffe, J.L., D’lugos, A.C., El‐Sohemy, A., & Luden, N.D. (2016). Caffeine and 3-km cycling performance: Effects of mouth rinsing, genotype, and time of day. Scandinavian Journal of Medicine & Science in Sports, 26(6), 613619. PubMed ID: 26062916 doi:10.1111/sms.12501

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Pickering, C. (2019). Are caffeine’s performance-enhancing effects partially driven by its bitter taste? Medical Hypotheses, 131, 109301. PubMed ID: 31443771 doi:10.1016/j.mehy.2019.109301

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Pomportes, L., Brisswalter, J., Casini, L., Hays, A., & Davranche, K. (2017). Cognitive performance enhancement induced by caffeine, carbohydrate and guarana mouth rinsing during submaximal exercise. Nutrients, 9(6), 589. doi:10.3390/nu9060589

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Ribeiro, J.A., & Sebastiao, A.M. (2010). Caffeine and adenosine. Journal of Alzheimer’s Disease, 20(Suppl. 1), S3S15. doi:10.3233/JAD-2010-1379

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Rousmans, S., Robin, O., Dittmar, A., & Vernet-Maury, E. (2000). Autonomic nervous system responses associated with primary tastes. Chemical Senses, 25(6), 709718. PubMed ID: 11114149 doi:10.1093/chemse/25.6.709

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Ruiz-Moreno, C., Lara, B., Salinero, J.J., Brito, D.S.D., Ordovás, J.M., & Del Coso, J. (2020). Time course of tolerance to adverse effects associated with the ingestion of a moderate dose of caffeine. European Journal of Nutrition. Advance online publication. PubMed ID: 31900579 doi:10.1007/s00394-019-02167-2

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Sainani, K.L. (2018). The problem with “magnitude-based inference”. Medicine & Science in Sports & Exercise, 50(10), 21662176. PubMed ID: 29683920 doi:10.1249/MSS.0000000000001645

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Sainani, K.L., Lohse, K.R., Jones, P.R., & Vickers, A. (2019). Magnitude-based inference is not Bayesian and is not a valid method of inference. Scandinavian Journal of Medicine & Science in Sports, 29(9), 14281436. PubMed ID: 31149752 doi:10.1111/sms.13491

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Salinero, J.J., Lara, B., Abian-Vicen, J., Gonzalez-Millán, C., Areces, F., Gallo-Salazar, C., . . . Del Coso, J. (2014). The use of energy drinks in sport: Perceived ergogenicity and side effects in male and female athletes. British Journal of Nutrition, 112(9), 14941502. PubMed ID: 25212095 doi:10.1017/S0007114514002189

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Saunders, B., de Oliveira, L.F., da Silva, R.P., de Salles Painelli, V., Gonçalves, L.S., Yamaguchi, G., . . . Gualano, B. (2017). Placebo in sports nutrition: A proof-of-principle study involving caffeine supplementation. Scandinavian Journal of Medicine & Science in Sports, 27(11), 12401247. PubMed ID: 27882605 doi:10.1111/sms.12793

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Sinclair, J., & Bottoms, L. (2014). The effects of carbohydrate and caffeine mouth rinsing on arm crank time-trial performance. Journal of Sports Research, 1(2), 3444.

    • Search Google Scholar
    • Export Citation
  • Skinner, T.L., Desbrow, B., Arapova, J., Schaumberg, M.A., Osborne, J., Grant, G.D., . . . Leveritt, M.D. (2019). Women experience the same ergogenic response to caffeine as men. Medicine & Science in Sports & Exercise, 51(6), 11951202. PubMed ID: 30629046 doi:10.1249/MSS.0000000000001885

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Skinner, T.L., Jenkins, D.G., Taaffe, D.R., Leveritt, M.D., & Coombes, J.S. (2013). Coinciding exercise with peak serum caffeine does not improve cycling performance. Journal of Science and Medicine in Sport, 16(1), 5459. PubMed ID: 22658588 doi:10.1016/j.jsams.2012.04.004

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Souissi, N., Bessot, N., Chamari, K., Gauthier, A., Sesboüé, B., & Davenne, D. (2007). Effect of time of day on aerobic contribution to the 30‐s Wingate test performance. Chronobiology International, 24(4), 739748. PubMed ID: 17701684 doi:10.1080/07420520701535811

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Tanimura, S., & Mattes, R.D. (1993). Relationships between bitter taste sensitivity and consumption of bitter substances. Journal of Sensory Studies, 8(1), 3141. doi:10.1111/j.1745-459X.1993.tb00200.x

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Van Cutsem, J., De Pauw, K., Marcora, S., Meeusen, R., & Roelands, B. (2018). A caffeine-maltodextrin mouth rinse counters mental fatigue. Psychopharmacology, 235(4), 947958. doi:10.1007/s00213-017-4809-0

    • Crossref
    • Search Google Scholar
    • Export Citation
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