The purpose of this study was to investigate the effect of oral allithiamine administration on isokinetic parameters of muscle performance and lactate accumulation prior to, during, and in recovery from isokinetic exercise. A double-blind, counterbalanced, crossover experimental design utilizing aBiodex System 2 Isokinetic Dynamometer was used to test 15 healthy college students. Subjects orally ingested either 1 g · ${\text{day}}^{-1}$ of a thiamin derivative, allithiamine, or a placebo for 5 days and then performed six exercise sets of knee extension and flexion. ANOVA revealed no significant differences between treatment conditions in peak torque, mean peak torque, average power, or total work performed (p > .05). Likewise, lactate accumulation was not significantly different between treatment conditions at any measurement point (p > .05). The absence of significant differences suggests that oral allithiamine administration does not enhance isokinetic parameters of muscle performance or lactate accumulation prior to, during, and following isokinetic exercise.