The effects of ingesting carbohydrate drinks on fatigue druting intermittent, high-intensity cycling in men and women were determined. Physically active but untrained women (n = 7) and ment (n = 9) completed one practice trial and two experimental sessions separate by 1 week. Sessions consisted of repeated 1-min cycling bouts on a bicycle ergometer at 120–130% $\dot{\mathrm{V}}{\mathrm{O}}_2\text{max}$ exercise (18% CHO) and every 20 min during exercise (6% CHO). Plasma glucose and insulin were higher, RPE for the legs was lower, and time to fatigue was longer in CHO than P. Men's and women's responses were not different for any variable measured. These data suggest a beneficial role of CHO drinks on performance of intermittent, high-intensity exercise in men and women.