Effect of Low- and High-Carbohydrate Diets on the Plasma Glutamine and Circulating Leukocyte Responses to Exercise

in International Journal of Sport Nutrition and Exercise Metabolism

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Michael Gleeson
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Andrew K. Blannin
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Neil P. Walsh
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Nicolette C. Bishop
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Anya M. Clark
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We examined the effects of a low-carbohydrate (CHO) diet on the plasma glutamine and circulating leukocyte responses to prolonged strenuous exercise. Twelve untrained male subjects cycled for 60 min at 70% of maximal oxygen uptake on two separate occasions, 3 days apart. All subjects performed the first exercise task after a normal diet: they completed the second exercise task after 3 days on either a high-CHO diet (75±8% CHO, n = 6) or a low-CHO diet (7±4% CHO, n = 6). The low-CHO diet was associated with a larger rise in plasma cortisol during exercise, a greater fall in the plasma glutamine concentration during recovery, and a larger neutrophilia during the postexercise period. Exercise on the high-CHO diet did not affect levels of plasma glutamine and circulating leukocytes. We conclude that CHO availability can influence the plasma glutamine andcirculaling leukocyte responses during recovery from intense prolonged exercise.

The authors are with the School of Sport and Exercise Sciences, University of Birmingham, England. Direct correspondence to Michael Gleeson. School of Sport and Exercise Sciences, University of Birmingham, Edgbaston. Birmingham. B152TT. England.

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