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Ten physically active, untrained, college-aged males (26.4 ± 5.8 years old) received creatine (CR. 5 g creatine monohydrate + 3 g dextrose) and placebo (PLA, 7 g dextrose) supplementation four times per day for 5 days in a double-blind, randomized, balanced, crossover design. Performance was assessed during maximal and three repeated submaximal bouts of isometric knee extension and handgrip exercise. CR supplementation significantly increased (p < .05) maximal isometric strength during knee extension but not during handgrip exercise. CR supplementation increased time to fatigue during each of the three bouts of submaximal knee extension and handgrip exercise when compared to the PLA trials. These findings suggest that CR supplementation can increase maximal strength and lime to fatigue during isometric exercise. However, the improvements in maximal isometric strength following CR supplementation appear to be restricted to movements performed with a large muscle mass.
The authors are with the Exercise Biochemistry Laboratory, Department of Kinesiology, California State University, Northridge, 18111 Nordhoff St., Northridge, CA 91330-8287. Direct correspondence to B.B. Yaspelkis III.