Previous studies in endurance athletes have indicated that block periodization (BP) can be a good alternative to the more traditional organization of training despite the fact that the total volume and intensity of the training are similar. However, these studies usually last only 4–12 wk. The aim of the present single-case study was to investigate the consequences of 58 wk with systematic BP of low-intensity training (LIT), moderate-intensity training (MIT), and high-intensity interval training (HIT) including incorporation of heavy strength training. It is important that a maintenance stimulus on the nonprioritized training modalities was added in the different training blocks. Performance-related variables were tested regularly during the intervention. The studied cyclist started with a maximal oxygen uptake (VO₂max) of 73.8 mL · kg⁻¹ · min⁻¹, peak aerobic power (W_max) of 6.14 W/kg, and a power output at 3 mmol/L blood lactate concentration (Power_3la-) of 3.6 W/kg. Total training volume during the 58-wk intervention was 678 h, of which 452 h were LIT (67%), 124 h were MIT (18%), 69 h were HIT (10%), and 34 h were heavy strength training (5%). The weekly training volume had a large range depending on the focus of the training block. After the intervention the cyclist’s VO₂max was 87 mL · kg⁻¹ · min⁻¹, W_max was 7.35 W/kg, and Power_3la- was 4.9 W/kg. This single case indicates that the present training program can be a good alternative to the more traditional organization of long-term training of endurance athletes. However, a general recommendation cannot be given based on this single-case study.