Purpose: The power clean and other weightlifting movements are commonly used in the development of muscle power. However, there is a paucity of research examining the use of the hook grip (HG) in weightlifting performance. Therefore, the purpose of this study was to compare 1-repetition maximum (1RM) and kinetic, kinematic, and qualitative variables across a range of loads (75–100%) during power-clean performance with an HG and a closed grip. Methods: A total of 11 well-trained men (power-clean 1RM = 113.4 [15.9] kg, 1.34 × body mass) with at least 3 mo of HG experience volunteered to participate. Following a familiarization session, 1RM testing with the HG and closed grip were completed 5–7 d apart in a randomized order. Barbell kinetic and kinematic variables were recorded via a force platform and dual linear position transducer system. Results: All subjects had a greater 1RM with the HG than with the closed grip (P < .001, effect size [ES] = 0.43). Peak velocity (ES = 0.41–0.70), peak power (ES = 0.43–0.61), peak force (ES = 0.50–0.57), and catch height (ES = 0.40–0.96) were significantly greater (P < .05) when using the HG at all or most of the submaximal intensities. In addition, subjects reported significantly greater perceptions of grip security, power, and technical competency at submaximal but not maximal loads. Conclusions: Athletes and coaches who implement weightlifting movements in their physical preparation should adopt the HG where possible. Furthermore, researchers and sport scientists should control and report the grip type used when performing weightlifting-type movements.