Purpose: To describe the load–velocity relationship and the effects of increasing loads on spatiotemporal and derived kinetic variables of sprinting using weighted vests (WV) in soccer players and determining the load that maximizes power output. Methods: A total of 23 soccer players (age 20.8 [1.5] y) performed 10 maximal 30-m sprints wearing a WV with 5 different loads (0%, 10%, 20%, 30%, and 40% body mass [BM]). Sprint velocity and time were collected using a radar device and wireless photocells. Mechanical outputs were computed using a recently developed valid and reliable field method that estimates the step-averaged ground-reaction forces during overground sprint acceleration from anthropometric and spatiotemporal data. Raw velocity–time data were fitted by an exponential function and used to calculate the net horizontal ground-reaction forces and horizontal power output. Individual linear force–velocity relationships were then extrapolated to calculate the theoretical maximum horizontal force (F₀) and velocity and the ratio of force application (proportion of the total force production that is directed forward at sprint start). Results: Magnitude-based inferences showed an almost certain decrease in F₀ (effect size = 0.78–3.35), maximum power output (effect size = 0.78–3.81), and maximum ratio of force (effect size = 0.82–3.87) as the load increased. The greatest changes occurred with loads heavier than 20% BM, especially in ratio of force. In addition, the maximum power was achieved under unloaded conditions. Conclusions: Increasing load in WV sprinting affects spatiotemporal and kinetic variables. The greatest change in ratio of force happened with loads heavier than 20% BM. Thus, the authors recommend the use of loads ≤20% BM for WV sprinting.