Purpose: To analyze and compare the effects of 4 different resisted sprint training (RST) modalities on youth soccer players’ performance after 8 weeks of training. Methods: Forty-eight youth soccer players were first randomly assigned to 4 groups and only then completed 8 weeks of RST: horizontal resisted sprint, vertical resisted sprint (VRS), combined resisted sprint, and unresisted sprint. Performance in horizontal and vertical jumps, sprint, and change of direction (COD) ability were assessed 1 week before and after the training intervention. Magnitude-based inference analysis was performed for calculating within-group pre–post differences. In addition, an analysis of covariance test was performed for between-group comparison, using the pretest values as covariates. After that, the analysis of covariance P values and the effect statistic were transformed to magnitude-based inference. Results: Within-group outcomes showed that all resisted training modalities experienced improvements in sprint (small to moderate) and COD (small to large) performance. Moreover, all groups, except unresisted sprint, enhanced the horizontal jump performance. However, only VRS improved on vertical jump. Between-group comparison outcomes revealed that only VRS improved the sprint time compared with horizontal resisted sprint (moderate) and COD performance compared with all groups (moderate to large). In addition, VRS enhanced the countermovement jump performance (small to large) compared with the other groups. Conclusions: Independent of the orientation of the resistance applied, RST is an effective training method for improving sprinting and COD performance. Nevertheless, VRS may promote greater improvements on sprint and COD ability and have a positive additional effect on countermovement jump performance and the reduction of COD deficit.