Body Composition Over the Menstrual and Oral Contraceptive Cycle in Trained Females

in International Journal of Sports Physiology and Performance

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Beatriz Rael
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Nuria Romero-Parra
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Víctor M. Alfaro-Magallanes
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Laura Barba-Moreno
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Rocío Cupeiro
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Xanne Janse de Jonge
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Ana B. Peinado
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on Behalf of the IronFEMME Study Group
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Purpose: The influence of female sex hormones on body fluid regulation and metabolism homeostasis has been widely studied. However, it remains unclear whether hormone fluctuations throughout the menstrual cycle (MC) and with oral contraceptive (OC) use affect body composition (BC). Thus, the aim of this study was to investigate BC over the MC and OC cycle in well-trained females. Methods: A total of 52 eumenorrheic and 33 monophasic OC-taking well-trained females participated in this study. Several BC variables were measured through bioelectrical impedance analysis 3 times in the eumenorrheic group (early follicular phase, late follicular phase, and midluteal phase) and on 2 occasions in the OC group (withdrawal phase and active pill phase). Results: Mixed linear model tests reported no significant differences in the BC variables (body weight, body mass index, basal metabolism, fat mass, fat-free mass, and total body water) between the MC phases or between the OC phases (P > .05 for all comparisons). Trivial and small effect sizes were found for all BC variables when comparing the MC phases in eumenorrheic females, as well as for the OC cycle phases. Conclusions: According to the results, sex hormone fluctuations throughout the menstrual and OC cycle do not influence BC variables measured by bioelectrical impedance in well-trained females. Therefore, it seems that bioimpedance analysis can be conducted at any moment of the cycle, both for eumenorrheic women and women using OC.

Rael, Romero-Parra, Alfaro-Magallanes, Barba-Moreno, Cupeiro, and Peinado are with the LFE Research Group, Dept of Health and Human Performance, Faculty of Physical Activity and Sport Science (INEF), Universidad Politécnica de Madrid, Madrid, Spain. Janse de Jonge is with the School of Environmental and Life Sciences, University of Newcastle, NSW, Australia.

Romero-Parra (n.romero@upm.es) is corresponding author.
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  • Expand
  • 1.

    Stachenfeld NS. Sex hormone effects on body fluid regulation. Exerc Sport Sci Rev. 2008;36(3):152159. PubMed ID: 18580296 doi:10.1097/JES.0b013e31817be928

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 2.

    Marchand GB, Carreau A-M, Weisnagel SJ, et al. Increased body fat mass explains the positive association between circulating estradiol and insulin resistance in postmenopausal women. Am J Physiol Endocrinol Metab. 2018;314(5):E448E456. doi:10.1152/ajpendo.00293.2017

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 3.

    Janse de Jonge X, Thompson B, Han A. Methodological recommendations for menstrual cycle research in sports and exercise. Med Sci Sports Exerc. 2019;51(12):26102617. doi:10.1249/MSS.0000000000002073

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 4.

    Janse de Jonge X. Effects of the menstrual cycle on exercise performance. Sports Med. 2003;33(11):833851. PubMed ID: 12959622 doi:10.2165/00007256-200333110-00004

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 5.

    Kitajima Y, Ono Y. Estrogens maintain skeletal muscle and satellite cell functions. J Endocrinol. 2016;229(3):267275. PubMed ID: 27048232 doi:10.1530/JOE-15-0476

  • 6.

    Sung E, Han A, Hinrichs T, Vorgerd M, Manchado C, Platen P. Effects of follicular versus luteal phase-based strength training in young women. Springerplus. 2014;3(1):668. doi:10.1186/2193-1801-3-668

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 7.

    Hansen M. Female hormones: do they influence muscle and tendon protein metabolism? Proc Nutr Soc. 2018;77(1):3241. PubMed ID: 28847313 doi:10.1017/S0029665117001951

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 8.

    Stachenfeld NS, Keefe DL. Estrogen effects on osmotic regulation of AVP and fluid balance. Am J Physiol Endocrinol Metab. 2002;283(4):E711E721. doi:10.1152/ajpendo.00192.2002

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 9.

    Cumberledge EA, Myers C, Venditti JJ, Dixon CB, Andreacci JL. The effect of the menstrual cycle on body composition determined by contact-electrode bioelectrical impedance analyzers. Int J Exerc Sci. 2018;11(4):625. PubMed ID: 29541335

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 10.

    Teixeira ALS, Damasceno VO, Dias MRC, Lamounier JA, Gardner RM. Association between different phases of menstrual cycle and body image measures of perceived size, ideal size, and body dissatisfaction. Percept Mot Skills. 2013;117(3):892902. PubMed ID: 24665805 doi:10.2466/24.27.PMS.117x31z1

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 11.

    Meaden PM, Hartlage SA, Cook-Karr J. Timing and severity of symptoms associated with the menstrual cycle in a community-based sample in the Midwestern United States. Psychiatry Res. 2005;134(1):2736. PubMed ID: 15808287 doi:10.1016/j.psychres.2005.01.003

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 12.

    Tomazo-Ravnik T, Jakopič V. Changes in total body water and body fat in young women in the course of menstrual cycle. Int J Anthropol. 2006;21(1):5560. doi:10.1007/s11599-006-9007-0

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 13.

    Hicks CS, McLester CN, Esmat TA, McLester JR. A comparison of body composition across two phases of the menstrual cycle utilizing dual-energy X-Ray absorptiometry, air displacement plethysmography, and bioelectrical impedance analysis. Int J Exerc Sci. 2017;10(8):1235. PubMed ID: 29399250

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 14.

    Daniusevičiūtė L, Brazaitis M, Skurvydas A, et al. Changes in concentration of creatine kinase, body composition and lipoprotein during menstrual cycle. Ugdymas Kuno Kultura. 2010;77(2):1117 .

    • Search Google Scholar
    • Export Citation
  • 15.

    Gualdi-Russo E, Toselli S. Influence of various factors on the measurement of multifrequency bioimpedance. Homo. 2002;53(1):116. PubMed ID: 12365353 doi:10.1078/0018-442X-00035

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 16.

    Stachenfeld NS, Taylor HS. Effects of estrogen and progesterone administration on extracellular fluid. J Appl Physiol. 2004;96(3):10111018. PubMed ID: 14660504 doi:10.1152/japplphysiol.01032.2003

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 17.

    Di Carlo C, Gargano V, Sparice S, et al. Short-term effects of an oral contraceptive containing oestradiol valerate and dienogest on bone metabolism and bone mineral density: an observational, preliminary study. Eur J Contracept Reprod Helath Care. 2013;18(5):388393. doi:10.3109/13625187.2013.811483

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 18.

    Burrows M, Peters CE. The influence of oral contraceptives on athletic performance in female athletes. Sports Med. 2007;37(7):557574. PubMed ID: 17595152 doi:10.2165/00007256-200737070-00001

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 19.

    Luglio HF. Estrogen and body weight regulation in women: the role of estrogen receptor alpha (ER-α) on adipocyte lipolysis. Acta Med Indones. 2014;46(4):333338. PubMed ID: 25633552

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 20.

    Gleichauf C, Roe D. The menstrual cycle’s effect on the reliability of bioimpedance measurements for assessing body composition. Am J Clin Nutr. 1989;50(5):903907. PubMed ID: 2816797 doi:10.1093/ajcn/50.5.903

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 21.

    Association WM. World Medical Association declaration of Helsinki. Ethical principles for medical research involving human subjects. Bull World Health Organ. 2001;79(4):373.

    • Search Google Scholar
    • Export Citation
  • 22.

    Rechichi C, Dawson B, Goodman C. Athletic performance and the oral contraceptive. Int J Sports Physiol Perform. 2009;4(2):151162. PubMed ID: 19567919 doi:10.1123/ijspp.4.2.151

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 23.

    Vasold KL, Parks AC, Phelan DM, Pontifex MB, Pivarnik JM. Reliability and validity of commercially available low-cost bioelectrical impedance analysis. Int J Sport Nutr Exerc Metab. 2019;29(4):406410. PubMed ID: 30507268

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 24.

    Khalil SF, Mohktar MS, Ibrahim F. The theory and fundamentals of bioimpedance analysis in clinical status monitoring and diagnosis of diseases. Sensors. 2014;14(6):1089510928. PubMed ID: 24949644 doi:10.3390/s140610895

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 25.

    Hopkins W, Marshall S, Batterham A, Hanin J. Progressive statistics for studies in sports medicine and exercise science. Med Sci Sports Exerc. 2009;41(1):313. doi:10.1249/MSS.0b013e31818cb278

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 26.

    Fernández-Elías VE, Ortega JF, Nelson RK, Mora-Rodriguez R. Relationship between muscle water and glycogen recovery after prolonged exercise in the heat in humans. Eur J Appl Physiol. 2015;115(9):19191926. doi:10.1007/s00421-015-3175-z

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 27.

    Calzone WL, Silva C, Keefe DL, Stachenfeld NS. Progesterone does not alter osmotic regulation of AVP. Am J Physiol Regul Integr Comp Physiol. 2001;281(6):R2011R2020. PubMed ID: 11705788 doi:10.1152/ajpregu.2001.281.6.R2011

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 28.

    Cohen CJ. Variation of body potassium mass in humans. Hum Biol. 1973;45(4):553561. PubMed ID: 4780992

  • 29.

    Dadlani A, Chandwani S, Desai C, Pandya K. Serum electrolytes during various phases of menstrual cycle. Indian J Physiol Pharmacol. 1981;26(4):302306.

    • Search Google Scholar
    • Export Citation
  • 30.

    Janowsky DS, Berens SC, Davis JM. Correlations between mood, weight, and electrolytes during the menstrual cycle: a renin-angiotensin-aldosterone hypothesis of premenstrual tension. Psychosom Med. 1973;35(2):143154. PubMed ID: 4350142 doi:10.1097/00006842-197303000-00007

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 31.

    Reeves BD, Garvin JE, McElin TW. Premenstrual tension: symptoms and weight changes related to potassium therapy. Am J Obstet Gynecol. 1971;109(7):10361041. PubMed ID: 4928336 doi:10.1016/0002-9378(71)90287-0

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 32.

    White CP, Hitchcock CL, Vigna YM, Prior JC. Fluid retention over the menstrual cycle: 1-year data from the prospective ovulation cohort. Obstet Gynecol Int. 2011;2011:138451. PubMed ID: 21845193 doi:10.1155/2011/138451

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
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