Purpose: Different studies indicate that female players in team sports such as soccer tend to have a lower change-of-direction (COD) deficit (CODD) than their male counterparts and that players who performed better in linear and curved sprints tended to have a worse CODD, suggesting that maximum speed does not equate to a faster COD. This study assessed how performance variables related to speed and jumping influence the variability of %CODD among adult highly trained female soccer players. Methods: Fifty-two highly trained female soccer players (age 23.1 [3.25] y; height 163.6 [5.49] cm; weight 59.7 [5.71] kg) participated in this study and performed 180COD, 40-m sprint, countermovement jump, and standing broad jump tests. Results: Significant correlations were found between 180CODL, %CODDR, %CODDL, and between-limbs standing broad jump asymmetry (r = .28–.74). A very large correlation existed between %CODDR and %CODDL (r = .91). Regression analyses indicated a strong inverse relationship between the 10-m sprint time and %CODDR and %CODDL. No predictive models were found for 180COD in either limb. Differences in performance variables such as 180CODR, 180CODL, and asymmetry %CODD were significant between the high- and low-%CODD groups, with moderate to large effect sizes. Conclusion: The present study suggests that specific physical-performance variables, particularly acceleration and unilateral horizontal jumping, are vital to improving COD in highly trained female soccer players, highlighting the need for specific training interventions.