Purpose: This study investigated the postactivation performance-enhancement effect of maximal voluntary isometric contraction (MVIC) at the starting position on power-clean performance over a series of contrast sets. Methods: Eighteen male (age: 31 [3.7] y, body mass: 76.8 [9.1] kg, height: 175.0 [5.2] cm) and 2 female (age: 27.5 [3.5] y, body mass: 53.3.8 [2.0] kg, height: 158.5 [4.9] cm) resistance-trained individuals performed a contrast postactivation performance-enhancement protocol (isometric contrast training condition [ISO]) consisting of 3 sets of 3 MVICs alternated with 3 power cleans, with an intracontrast rest period of 1 minute. A control protocol consisted of 3 sets of 3 power cleans were performed in a separate session. Barbell velocity during the power clean was measured as an indicator of performance. Results: A significant time effect was observed for both mean velocity (MV; P < .001) and peak velocity (PV; P = .008). Time × group (P = .415–.444) and group (P = .158–.210) effects showed no significant difference for either MV or PV. However, differences in MV and PV between the corresponding sets of ISO and control condition exceeded the minimum worthwhile change, showing a small to moderate effect (MV: d = 0.38–0.50, PV: d = 0.35–0.50) in favor of ISO. There was no significant difference in rating of perceived exertion between conditions (P = .385, d = 0.22). Conclusion: Power-clean performance was potentiated after 1 minute of rest following 3 repetitions of MVIC across 3 sets. Furthermore, the ISO protocol did not result in greater perception of exertion. These results indicate that coaches may incorporate MVICs as the postactivation performance-enhancement stimulus during contrast training involving the power-clean exercise.