Static stretching (SS) is widely used in warm-ups before training and competition. A growing amount of research, however, has demonstrated that SS can impair muscle performance, leading to a reevaluation of optimal warm-up protocols. This commentary discusses many of the methodological issues that can influence conclusions about the acute effects of SS on performance. One difficulty in interpreting the literature is the lack of control or communication about the volume and intensity of the various stretching treatments used. Another major issue is the failure of many researchers to evaluate SS as it is used in practice, particularly the interaction with the other general and sport-specific components of the warm-up. Acute warm-up effects on performance should be considered in conjunction with potential effects on injury prevention. Future directions in research include optimizing general and sport-specific warm-ups, time course of physiological and performance effects, and individualization of warm-ups according to fitness and skill level.