The ACTN3 XX Genotype’s Underrepresentation in Japanese Elite Wrestlers

in International Journal of Sports Physiology and Performance
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Purpose:

To examine the relationship between ACTN3 polymorphisms and level of athletic performance in Japanese wrestlers.

Methods:

The control group consisted of 243 healthy Japanese individuals. The authors divided 135 wrestlers into 3 groups based on their results in national or international competitions. They classified as elite 24 wrestlers who had placed in the top 8 in a world championship or participated in Olympic games, 28 wrestlers who had participated in world championships or become champions in Japan’s national championships were classified as subelite, and 83 wrestlers were classified as national (N-W, ie, national-level wrestler). In addition, the authors combined the elite and subelite to form the classification international-level wrestlers (I-W).

Results:

The frequency of the null X allele and the XX genotype were significantly lower in the I-W group than in the control group. However, there was no significant difference in ACTN3 genotype or allele frequency between the N-W and control groups. The frequency of the ACTN3 XX genotype in the elite groups was lower than that of all groups, and a linear tendency was observed between ACTN3 XX genotype and athletic status.

Conclusions:

In conclusion, the data indicated that ACTN3 polymorphisms were related to athletic performance in Japanese wrestlers.

Kikuchi is with the Graduate School of Health and Sport Science; Min and Nakazato, the Laboratory of Exercise Physiology; and Igawa, the Laboratory of Sports Nutrition, Nippon Sport Science University, Tokyo, Japan. Ueda is with the Faculty of Health and Nutrition, Bunkyo University, Kanagawa, Japan.