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This investigation aimed to ascertain a detailed physiological profile of recovery from intermittentsprint exercise of athletes familiar with the exercise and to investigate if athletes receive a protective effect on markers of exercise-induced muscle damage (EIMD), inflammation, and oxidative stress after a repeated exposure to an identical bout of intermittent-sprint exercise.


Eight well-trained male team-sport athletes of National League or English University Premier Division standard (mean ± SD age 23 ± 3 y, VO2max 54.8 ± 4.6 mL · kg−1 · min−1) completed the Loughborough Intermittent Shuttle Test (LIST) on 2 occasions, separated by 14 d. Maximal isometric voluntary contraction (MIVC), countermovement jump (CMJ), creatine kinase (CK), C-reactive protein (CRP), interleukin-6 (IL-6), F2-isoprostanes, and muscle soreness (DOMS) were measured before and up to 72 h after the initial and repeated LISTs.


MIVC, CMJ, CK, IL-6, and DOMS all showed main effects for time (P < .05) after the LIST, indicating that EIMD was present. DOMS peaked at 24 h after LIST 1 (110 ± 53 mm), was attenuated after LIST 2 (56 ± 39 mm), and was the only dependent variable to demonstrate a reduction in the second bout (P = .008). All other markers indicated that EIMD did not differ between bouts.


Well-trained games players experienced EIMD after exposure to both exercise tests, despite being accustomed to the exercise type. This suggests that well-trained athletes receive a very limited protective effect from the first bout.

Leeder and Howatson are with the Dept of Sport, Exercise and Rehabilitation, Northumbria University, Northumbria, UK. Leeder and van Someren are with the English Inst of Sport, UK. Gaze is with the Dept of Chemical Pathology, St George’s Healthcare NHS Trust, London, UK. Jewellis with the Faculty of Health and Social Care Sciences, Kingston University and St George’s University of London, London, UK. Deshmukh, Shah, and Barker are with the School of Pharmacy and Chemistry, Kingston University, Kingston-Upon-Thames, Surrey, UK.