Observational studies show a relationship between elevated serum uric acid (UA) and better physical performance and muscle function. The purpose of this paper was to determine whether regular participation in an exercise intervention, known to improve physical functioning, would result in increased serum UA. For this study, 424 older adults at risk for physical disability were randomized to participate in either a 12-mo moderate-intensity physical activity (PA) or a successful aging (SA) health education intervention. UA was measured at baseline, 6, and 12 mo (n = 368, 341, and 332, respectively). Baseline UA levels were 6.03 ± 1.52 mg/dl and 5.94 ± 1.55 mg/dl in the PA and SA groups, respectively. The adjusted mean UA at month 12 was 4.8% (0.24 mg/dl) higher in the PA compared with the SA group (p = .028). Compared with a health education intervention, a 1-yr PA intervention results in a modest increase in systemic concentration of UA in older adults at risk for mobility disability.
Beavers and Nicklas are with the Dept. of Internal Medicine, and Hsu, the Dept. of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC. Serra is with the Division of Gerontology and Geriatric Medicine, University of Maryland School of Medicine, Baltimore, MD. Yank is with the Dept. of Medicine, Stanford University, Stanford, CA. Pahor is with the Dept. of Aging and Geriatric Research, University of Florida, Gainesville, FL.