Moderate Intensity Exercise Is Associated With Decreased Angiotensin-converting Enzyme, Increased β2-Adrenergic Receptor Gene Expression, and Lower Blood Pressure in Middle-Aged Men

in Journal of Aging and Physical Activity
Restricted access

Purchase article

USD  $24.95

Student 1 year subscription

USD  $76.00

1 year subscription

USD  $101.00

Student 2 year subscription

USD  $144.00

2 year subscription

USD  $189.00


The purpose of the current study was to characterize the role of aerobic exercise in the gene expression of the angiotensin-converting enzyme (ACE) and the β2-adrenergic receptor (ADRB2) in untrained men.


Twenty untrained middle-aged men were randomly assigned to exercise (Exe) and control (Con) groups. The Exe group performed aerobic exercises for eight weeks. ACE mRNA and ADRB2 mRNA were determined by PCR.


The expression of ACE in week 4 and in the Exe group decreased significantly (p < .001). ADRB2 in the Exe group, in week 4 and in week 8, was markedly higher, and blood pressure was significantly lower than in the Con group (p < .001). In the Con group ADRB2 mRNA decreased.


These results suggest that moderate intensity exercise promotes the leukocyte expression of gene markers that may affect blood pressure by improving cardiovascular fitness levels in middle-aged men.

Tartibian is with the Department of Exercise Physiology, Faculty of Physical Education and Sport Science, Urmia University, Urmia, Iran. Botelho Teixeria is with Faculdade De Ciencias Do Desporto E Educacao Fisica, University De Coimbra, Coimbra, Portugal. Baghaiee is with the Department of Physical Education and Sport Science, University of Mohaghegh Ardabili, Ardabil, Iran. Address author correspondence to Bakhtyar Tartibian at