Twelve-Week Exercise Influences Memory Complaint but not Memory Performance in Older Adults: A Randomized Controlled Study

in Journal of Aging and Physical Activity
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This study aimed to evaluate the effects of different types of exercise on memory performance and memory complaint after a 12-week intervention. Eighty community-dwelling volunteers, aged 66.96 ± 11.73 years, were randomly divided into four groups: resistance, cardiovascular, postural, and control groups (20 participants for each group). All participants were tested for their cognitive functions before and after their respective 12-week intervention using Rey memory words test, Prose memory test, and Memory Complaint Questionnaire (MAC-Q). Statistical analysis showed that the three experimental groups significantly improved MAC-Q scores in comparison with the control group (p < .05). The variation of MAC-Q scores and the variations of Rey and Prose memory tests scores were not correlated. These results indicate that the 12-week interventions exclusively influenced memory complaint but not memory performance. Further investigations are needed to understand the relation between memory complaint and memory performance, and the factors that can influence this relationship.

Iuliano, Fiorilli, Aquino, and Calcagno are with the Department of Medicine and Health Sciences, University of Molise, Campobasso, Italy. Di Costanzo is with the Department of Medicine and Health Sciences, Center for Research and Training in Aging Medicine, University of Molise, Campobasso, Italy. Di Cagno is with the Department of Health Sciences, University of Rome “Foro Italico”, Rome, Italy.

Address author correspondence to Giuseppe Calcagno at giuseppe.calcagno@unimol.it.
  • American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). Arlington, VA: American Psychiatric Publishing.

    • Search Google Scholar
    • Export Citation
  • Angevaren, M., Aufdemkampe, G., Verhaar, H.J., Aleman, A., & Vanhees, L. (2008). Physical activity and enhanced fitness to improve cognitive function in older people without known cognitive impairment. Cochrane Database of Systematic Reviews, (3), CD005381. PubMed doi:10.1002/14651858.CD005381

    • Search Google Scholar
    • Export Citation
  • Antikainen, R., Hänninen, T., Honkalampi, K., Hintikka, J., Koivumaa-Honkanen, H., Tanskanen, A., & Viinamäki, H. (2001). Mood improvement reduces memory complaints in depressed patients. European Archives of Psychiatry and Clinical Neuroscience, 251(1), 6–11. PubMed doi:10.1007/s004060170060

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Aquino, G., Iuliano, E., di Cagno, A., Vardaro, A., Fiorilli, G., Moffa, S., … Calcagno, G. (2016). Effects of combined training vs aerobic training on cognitive functions in COPD: a randomized controlled trial. International Journal of Chronic Obstructive Pulmonary Disease, 11(1), 711–718. PubMed doi:10.2147/COPD.S96663

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Barnes, D.E., & Yaffe, K. (2011). The projected effect of risk factor reduction on Alzheimer’s disease prevalence. The Lancet Neurology, 10(9), 819–828. PubMed doi:10.1016/S1474-4422(11)70072-2

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Battaglia, C., di Cagno, A., Fiorilli, G., Borrione, P., Giombini, A., Baralla, F., … Pigozzi, F. (2015). Participation in a 9-month selected physical exercise program enhances psychological well-being in a prison population. Criminal Behaviour and Mental Health, 25(5), 343–354. PubMed doi:10.1002/cbm.1922

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Brzycki, M. (1993). Strength testing—predicting a one-rep max from reps-to-fatigue. Journal of Physical Education, Recreation and Dance, 64(1), 88–90. doi:10.1080/07303084.1993.10606684

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Cassilhas, R.C., Viana, V.A., Grassmann, V., Santos, R.T., Santos, R.F., Tufik, S., & Mello, M.T. (2007). The impact of resistance exercise on the cognitive function of the elderly. Medicine and Science in Sports and Exercise, 39(8), 1401–1407. PubMed doi:10.1249/mss.0b013e318060111f

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Castellani, R.J., & Perry, G. (2014). Pathogenesis of Alzheimer’s disease. In R.M.Kostrzewa (Ed.), Handbook of neurotoxicity (pp. 2327–2337). New York, NY: Springer.

    • Search Google Scholar
    • Export Citation
  • Chang, Y.K., Pan, C.Y., Chen, F.T., Tsai, C.L., & Huang, C.C. (2012). Effect of resistance-exercise training on cognitive function in healthy older adults: a review. Journal of Aging and Physical Activity, 20(4), 497–517. PubMed doi:10.1123/japa.20.4.497

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Colcombe, S., & Kramer, A.F. (2003). Fitness effects on the cognitive function of older adults a meta-analytic study. Psychological Science, 14(2), 125–130. PubMed doi:10.1111/1467-9280.t01-1-01430

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Crook, T.H., Feher, E.P., & Larrabee, G.J. (1992). Assessment of memory complaint in age-associated memory impairment: the MAC-Q. International Psychogeriatrics, 4(2), 165–176. PubMed doi:10.1017/S1041610292000991

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Crumley, J.J., Stetler, C.A., & Horhota, M. (2014). Examining the relationship between subjective and objective memory performance in older adults: a meta-analysis. Psychology and Aging, 29(2), 250–263. PubMed doi:10.1037/a0035908

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Davenport, M.H., Hogan, D.B., Eskes, G.A., Longman, R.S., & Poulin, M.J. (2012). Cerebrovascular reserve: the link between fitness and cognitive function? Exercise and Sport Sciences Reviews, 40(3), 153–158. PubMed doi:10.1097/JES.0b013e3182553430

    • Search Google Scholar
    • Export Citation
  • Di Cagno, A., Sapere, N., Piazza, M., Aquino, G., Iuliano, E., Intrieri, M., & Calcagno, G. (2013). ACE and AGTR1 polymorphisms in elite rhythmic gymnastics. Genetic Testing and Molecular Biomarkers, 17(2), 99–103.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Elias, M.F., Robbins, M.A., & Elias, P.K. (1996). A 15-year longitudinal study of Halstead-Reitan neuropsychological test performance. The Journals of Gerontology Series B: Psychological Sciences and Social Sciences, 51(6), 331–334. PubMed doi:10.1093/geronb/51B.6.P331

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Erickson, K.I., Voss, M.W., Prakash, R.S., Basak, C., Szabo, A., Chaddock, L., … Kramer, A.F. (2011). Exercise training increases size of hippocampus and improves memory. Proceedings of the National Academy of Sciences, 108(7), 3017–3022. PubMed doi:10.1073/pnas.1015950108

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Etnier, J.L., Nowell, P.M., Landers, D.M., & Sibley, B.A. (2006). A meta-regression to examine the relationship between aerobic fitness and cognitive performance. Brain Research Reviews, 52(1), 119–130. PubMed doi:10.1016/j.brainresrev.2006.01.002

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Faul, F., Erdfelder, E., Lang, A.G., & Buchner, A. (2007). G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behavior Research Methods, 39(2), 175–191. PubMed doi:10.3758/BF03193146

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Flicker, L. (2010). Modifiable lifestyle risk factors for Alzheimer’s disease. Journal of Alzheimer’s Disease, 20(3), 803–811. PubMed doi:10.3233/JAD-2010-091624

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Folstein, M.F., Folstein, S.E., & McHugh, P.R. (1975). “Mini-mental state”: a practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research, 12(3), 189–198. PubMed doi:10.1016/0022-3956(75)90026-6

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Geerlings, M.I., Jonker, C., Bouter, L.M., Ad, H.J., & Schmand, B. (1999). Association between memory complaints and incident Alzheimer’s disease in elderly people with normal baseline cognition. American Journal Psychiatry, 156(4), 531–537. PubMed doi:10.1176/ajp.156.4.531

    • Search Google Scholar
    • Export Citation
  • Greer, T.L., Sunderajan, P., Grannemann, B.D., Kurian, B.T., & Trivedi, M.H. (2014). Does duloxetine improve cognitive function independently of its antidepressant effect in patients with major depressive disorder and subjective reports of cognitive dysfunction? Depression Research and Treatment, 2014, 627863. PubMed doi:10.1155/2014/627863

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Hannan, A.J. (2014). Review: environmental enrichment and brain repair: harnessing the therapeutic effects of cognitive stimulation and physical activity to enhance experience-dependent plasticity. Neuropathology and Applied Neurobiology, 40(1), 13–25. PubMed doi:10.1111/nan.12102

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Holzschneider, K., Wolbers, T., Röder, B., & Hötting, K. (2012). Cardiovascular fitness modulates brain activation associated with spatial learning. Neuroimage, 59(3), 3003–3014. PubMed doi:10.1016/j.neuroimage.2011.10.021

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Howieson, D.B., Mattek, N., Dodge, H.H., Erten-Lyons, D., Zitzelberger, T., & Kaye, J.A. (2015). Memory complaints in older adults: prognostic value and stability in reporting over time. SAGE Open Medicine, 3. PubMed doi:10.1177/2050312115574796

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Hülür, G., Hertzog, C., Pearman, A., Ram, N., & Gerstorf, D. (2014). Longitudinal associations of subjective memory with memory performance and depressive symptoms: between-person and within-person perspectives. Psychology and Aging, 29(4), 814–827. PubMed doi:10.1037/a0037619

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Hülür, G., Hertzog, C., Pearman, A.M., & Gerstorf, D. (2015). Correlates and moderators of change in subjective memory and memory performance: findings from the health and retirement study. Gerontology, 61(3), 232–240. PubMed doi:10.1159/000369010

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Iuliano, E., di Cagno, A., Aquino, G., Fiorilli, G., Mignogna, P., Calcagno, G., & Di Costanzo, A. (2015). Effects of different types of physical activity on the cognitive functions and attention in older people: a randomised controlled study. Experimental Gerontology, 70, 105–110. PubMed doi:10.1016/j.exger.2015.07.008

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Iuliano, E., di Cagno, A., Aquino, G., Pistone, E.M., Tsopani, D., Calcagno, G., … Fiorilli, G. (2016). Relationship between physical activity and cognitive decline in aging. Medicina dello Sport, 69(1), 151–161.

    • Search Google Scholar
    • Export Citation
  • Jedrziewski, M.K., Ewbank, D.C., Wang, H., & Trojanowski, J.Q. (2014). The impact of exercise, cognitive activities, and socialization on cognitive function results from the national long-term care survey. American Journal of Alzheimer’s Disease and Other Dementias, 29(4), 372–378. PubMed doi:10.1177/1533317513518646

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Johnson, B.L., & Nelson, J.K. (1979). Practical measurements for evaluation in physical education (4th ed.). Minneapolis, MN: Burgess.

  • Kelly, M.E., Loughrey, D., Lawlor, B.A., Robertson, I.H., Walsh, C., & Brennan, S. (2014). The impact of exercise on the cognitive functioning of healthy older adults: a systematic review and meta-analysis. Ageing Research Reviews, 16, 12–31. PubMed doi:10.1016/j.arr.2014.05.002

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Kline, G.M., Porcari, J.P., Hintermeister, R., Freedson, P.S., Ward, A.N.N., McCarron, R.F., … Rippe, J.M. (1987). Estimation of VO2max from a one-mile track walk, gender, age, and body weight. Medicine and Science in Sports and Exercise, 19(3), 253–259. PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Lautenschlager, N.T. (2014). Physical activity in Alzheimer’s disease: research in its infancy or why we need more randomized controlled trials. International Psychogeriatrics, 26(1), 1–7. PubMed doi:10.1017/S1041610213001981

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Lichtenstein, A.H., Appel, L.J., Brands, M., Carnethon, M., Daniels, S., Franch, H.A., … Wylie-Rosett, J. (2006). Diet and lifestyle recommendations revision 2006: a scientific statement from the American heart association nutrition committee. Circulation, 114(1), 82–96. PubMed doi:10.1161/CIRCULATIONAHA.106.176158

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Liu-Ambrose, T., Nagamatsu, L.S., Graf, P., Beattie, B.L., Ashe, M.C., & Handy, T.C. (2010). Resistance training and executive functions: a 12-month randomized controlled trial. Archives of Internal Medicine, 170(2), 170–178. PubMed doi:10.1001/archinternmed.2009.494

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Memel, M., Bourassa, K., Woolverton, C., & Sbarra, D.A. (2016). Body mass and physical activity uniquely predict change in cognition for aging adults. Annals of Behavioral Medicine, 50(3), 397–408. PubMed doi:10.1007/s12160-015-9768-2

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Meng, X.F., Yu, J.T., Wang, H.F., Tan, M.S., Wang, C., Tan, C.C., & Tan, L. (2014). Midlife vascular risk factors and the risk of Alzheimer’s disease: a systematic review and meta-analysis. Journal of Alzheimer’s Disease, 42(4), 1295–1310. PubMed doi:10.3233/JAD-140954

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Moher, D., Hopewell, S., Schulz, K.F., Montori, V., Gøtzsche, P.C., Devereaux, P.J., … Altman, D.G. (2010). CONSORT 2010 explanation and elaboration: updated guidelines for reporting parallel group randomised trials. Journal of Clinical Epidemiology, 63, e1–e37. PubMed doi:10.1016/j.jclinepi.2010.03.004

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Müller, N.C., Genzel, L., Konrad, B.N., Pawlowski, M., Neville, D., Fernández, G., … Dresler, M. (2016). Motor skills enhance procedural memory formation and protect against age-related decline. PLoS One, 11(6), e0157770. PubMed doi:10.1371/journal.pone.0157770

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Nagamatsu, L.S., Chan, A., Davis, J.C., Beattie, B.L., Graf, P., Voss, M.W., … Liu-Ambrose, T. (2013). Physical activity improves verbal and spatial memory in older adults with probable mild cognitive impairment: a 6-month randomized controlled trial. Journal of Aging Research, 2013, 861893. PubMed doi:10.1155/2013/861893

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Norton, S., Matthews, F.E., Barnes, D.E., Yaffe, K., & Brayne, C. (2014). Potential for primary prevention of Alzheimer’s disease: an analysis of population-based data. The Lancet Neurology, 13(8), 788–794. PubMed doi:10.1016/S1474-4422(14)70136-X

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Pate, R.R., O’Neill, J.R., & Lobelo, F. (2008). The evolving definition of “sedentary”. Exercise and Sport Sciences Reviews, 36(4), 173–178. PubMed doi:10.1097/JES.0b013e3181877d1a

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Reid, L.M., & MacLullich, A.M. (2006). Subjective memory complaints and cognitive impairment in older people. Dementia and Geriatric Cognitive Disorders, 22(5–6), 471–485. PubMed doi:10.1159/000096295

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Reisberg, B., & Gauthier, S. (2008). Current evidence for subjective cognitive impairment (SCI) as the pre-mild cognitive impairment (MCI) stage of subsequently manifest Alzheimer’s disease. International Psychogeriatrics, 20(1), 1–16. PubMed doi:10.1017/S1041610207006412

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Rey, A. (1958). Memorisationd’uneserie de 15 mots en 5 repetitions. In A.Rey (Ed.), L’examen clinique en psycologie. Paris, France: Presses Universitaires des France.

    • Search Google Scholar
    • Export Citation
  • Ruscheweyh, R., Willemer, C., Krüger, K., Duning, T., Warnecke, T., Sommer, J., … Flöel, A. (2011). Physical activity and memory functions: an interventional study. Neurobiology of Aging, 32(7), 1304–1319. PubMed doi:10.1016/j.neurobiolaging.2009.08.001

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Salvanes, A.G.V., Moberg, O., Ebbesson, L.O., Nilsen, T.O., Jensen, K.H., & Braithwaite, V.A. (2013). Environmental enrichment promotes neural plasticity and cognitive ability in fish. Proceedings of the Royal Society B: Biological Sciences, 280(1767), 20131331. PubMed doi:10.1098/rspb.2013.1331

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Shah, N.R., & Braverman, E.R. (2012). Measuring adiposity in patients: the utility of body mass index (BMI), percent body fat, and leptin. PLoS One, 7(4), e33308. PubMed doi:10.1371/journal.pone.0033308

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Slavin, M.J., Brodaty, H., Kochan, N.A., Crawford, J.D., Trollor, J.N., Draper, B., & Sachdev, P.S. (2010). Prevalence and predictors of “subjective cognitive complaints” in the Sydney memory and ageing study. The American Journal of Geriatric Psychiatry, 18(8), 701–710. PubMed doi:10.1097/JGP.0b013e3181df49fb

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Smith, P.J., Blumenthal, J.A., Hoffman, B.M., Cooper, H., Strauman, T.A., Welsh-Bohmer, K., … Sherwood, A. (2010). Aerobic exercise and neurocognitive performance: a meta-analytic review of randomized controlled trials. Psychosomatic Medicine, 72(3), 239–252. PubMed doi:10.1097/PSY.0b013e3181d14633

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Speisman, R.B., Kumar, A., Rani, A., Pastoriza, J.M., Severance, J.E., Foster, T.C., & Ormerod, B.K. (2013). Environmental enrichment restores neurogenesis and rapid acquisition in aged rats. Neurobiology of Aging, 34(1), 263–274. PubMed doi:10.1016/j.neurobiolaging.2012.05.023

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Spinnler, H., & Tognoni, G. (1987). Standardizzazione e taratura italiana di test neuropsicologici [Italian standardization and classification of neuropsychological tests]. The Italian Journal of Neurological Sciences, 8(Suppl 6), 1–120. PubMed

    • Search Google Scholar
    • Export Citation
  • Stern, Y. (2006). Cognitive reserve and Alzheimer disease. Alzheimer Disease and Associated Disorders, 20(2), 112–117. PubMed doi:10.1097/01.wad.0000213815.20177.19

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Stern, Y. (2009). Cognitive reserve. Neuropsychologia, 47(10), 2015–2028. PubMed doi:10.1016/j.neuropsychologia.2009.03.004

  • van Uffelen, J.G., Paw, M.J.C.A., Hopman-Rock, M., & van Mechelen, W. (2008). The effects of exercise on cognition in older adults with and without cognitive decline: a systematic review. Clinical Journal of Sport Medicine, 18(6), 486–500. PubMed doi:10.1097/JSM.0b013e3181845f0b

    • Crossref
    • Search Google Scholar
    • Export Citation
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