Impact of Sedentary Time on Chronic Kidney Disease and Disability Incidence in Community-Dwelling Japanese Older Adults: A 4-Year Prospective Cohort Study

in Journal of Aging and Physical Activity
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This study examined the association between the estimated glomerular filtration rate (eGFR) and disability incidence according to sedentary time in community-dwelling Japanese older adults. This prospective cohort study sampled 5,104 community-dwelling older adults (≥65 years) enrolled in a health promotion study in a general population. The participants (n = 4,457; ≥65 years) were monitored for inclusion in the long-term care insurance system for 4 years. This study used blood samples to assess eGFR. Cox proportional regression analysis was used to determine predictors of disability. In total, 461 participants (10.3%) became newly certified as needing long-term care insurance services. Cox regression models were adjusted for multiple confounders: eGFR < 45 ml/min/1.73 m2 (hazard ratio = 1.741, 95% confidence interval [1.193–2.539]) and eGFR < 45 ml/min/1.73 m2 with high sedentary time (≥8 hr) (hazard ratio = 4.367, 95% confidence interval [2.021–9.438]) remained significantly associated with disability incidence. Our findings suggest that in the case of chronic kidney disease, the disability incidence rate may be affected by sedentary time.

Su. Lee, Sa. Lee, Bae, Harada, Jung, Makino, and Shimada are with the Dept. of Preventive Gerontology, Center for Gerontology and Social Science, National Center for Geriatrics and Gerontology, Obu, Japan. Harada is also with the Graduate School of Human Development and Environment, Kobe University, Kobe, Japan.

Address author correspondence to Sungchul Lee at leesuys@ncgg.go.jp.
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