Restricted access

Purchase article

USD  $24.95

Student 1 year subscription

USD  $76.00

1 year subscription

USD  $101.00

Student 2 year subscription

USD  $144.00

2 year subscription

USD  $189.00

Besides its known function as a transport protein for testosterone and other steroid hormones, sex hormone–binding globulin (SHBG) is a biomarker associated with many adverse health effects. The aim of this study was to investigate the association of physical activity with SHBG serum levels in older adults. The physical activity and SHBG values for 1,259 older adults (43.4% female; 56.6% male) with a mean age of 75.6 ± 6.5 years were included in the analysis. The average daily walking duration was 104.2 ± 40.4 (mean ± SD) min. A positive dose–response relationship of daily walking duration with quartiles of SHBG was seen after adjustment for age, sex, history of cardiovascular diseases, diabetes, smoking, γ-glutamyl transferase, and C-reactive protein (p for trend = .010). However, this relationship disappeared after adjustment for body mass index (p for trend = .977). Body mass index seems to be an important determinant of SHBG and a possible confounding factor in the relationship of physical activity and SHBG.

Rothenbacher and Klenk are with Institute of Epidemiology and Medical Biometry, Ulm University, Ulm, Germany. Dallmeier and Denkinger are with Agaplesion Bethesda Clinic Ulm, Geriatric Medicine, Ulm University, Geriatric Center Ulm/Alb-Donau, Ulm, Germany. Boehm is with the Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore; and the Imperial College London, London, United Kingdom. Koenig is with Deutsches Herzzentrum München, Technische Universität München, DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany. Klenk is also with the Department of Geriatrics and Geriatric Rehabilitation, Robert-Bosch-Hospital, Stuttgart, Germany and the IB Hochschule Berlin, Studienzentrum Stuttgart, Stuttgart, Germany.

Rothenbacher (dietrich.rothenbacher@uni-ulm.de) is corresponding author.
  • Denkinger, M.D., Franke, S., Rapp, K., Weinmayr, G., Duran-Tauleria, E., Nikolaus, T., … ActiFE Ulm Study Group. (2010). Accelerometer-based physical activity in a large observational cohort—Study protocol and design of the activity and function of the elderly in Ulm (ActiFE Ulm) study. BMC Geriatrics, 10, 50. PubMed ID: 20663209 doi:10.1186/1471-2318-10-50

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Ding, E.L., Song, Y., Manson, J.E., Hunter, D.J., Lee, C.C., Rifai, N., … Liu, S. (2009). Sex hormone-binding globulin and risk of type 2 diabetes in women and men. The New England Journal of Medicine, 361(12), 1152–1163. PubMed ID: 19657112 doi:10.1056/NEJMoa0804381

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Elmlinger, M.W., Kühnel, W., Wormstall, H., & Döller, P.C. (2005). Reference intervals for testosterone, androstenedione and SHBG levels in healthy females and males from birth until old age. Clinical Laboratory, 51(11–12), 625–632. PubMed ID: 16329622

    • Search Google Scholar
    • Export Citation
  • Hammond, G.L., Wu, T.-S., & Simard, M. (2012). Evolving utility of sex hormone-binding globulin measurements in clinical medicine. Current Opinion in Endocrinology, Diabetes and Obesity, 19(3), 183–189. PubMed ID: 22531107 doi:10.1097/MED.0b013e328353732f

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Jefferis, B.J., Merom, D., Sartini, C., Wannamethee, S.G., Ash, S., Lennon, L.T., … Whincup, P.H. (2015). Physical activity and falls in older men: The critical role of mobility limitations. Medicine & Science in Sports & Exercise, 47(10), 2119–2128. PubMed ID: 25668406 doi:10.1249/MSS.0000000000000635

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Klenk, J., Dallmeier, D., Denkinger, M.D., Rapp, K., Koenig, W., Rothenbacher, D., & ActiFE Study Group. (2016). Objectively measured walking duration and sedentary behaviour and four-year mortality in older people. PLoS ONE, 11(4), e0153779. doi:10.1371/journal.pone.0153779

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Klenk, J., Denkinger, M., Nikolaus, T., Peter, R., Rothenbacher, D., Koenig, W., & ActiFE Study Group. (2013). Association of objectively measured physical activity with established and novel cardiovascular biomarkers in elderly subjects: Every step counts. Journal of Epidemiology & Community Health, 67(2), 194–197. PubMed ID: 22930799 doi:10.1136/jech-2012-201312

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Nelson, M.E., Rejeski, W.J., Blair, S.N., Duncan, P.W., Judge, J.O., King, A.C., … American Heart Association. (2007). Physical activity and public health in older adults: Recommendation from the American College of Sports Medicine and the American Heart Association. Circulation, 116(9), 1094–1105. PubMed ID: 17671236 doi:10.1161/CIRCULATIONAHA.107.185650

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Parsons, T.J., Sartini, C., Welsh, P., Sattar, N., Ash, S., Lennon, L.T., … Jefferis, B.J. (2017). Physical activity, sedentary behavior, and inflammatory and hemostatic markers in men. Medicine & Science in Sports & Exercise, 49(3), 459–465. PubMed ID: 28222056 doi:10.1249/MSS.0000000000001113

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Perry, J.R, Weedon, M.N., Langenberg, C., Jackson, A.U., Lyssenko, V., Sparsø, T., … Frayling, T.M. (2010). Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes. Human Molecular Genetics, 19(3), 535–544. PubMed ID: 19933169 doi:10.1093/hmg/ddp522

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Physical Activity Guidelines Advisory Committee report, 2008. To the Secretary of Health and Human Services. Part A: Executive summary. (2009). Nutrition Reviews, 67(2), 114–120. PubMed ID: 19178654 doi:10.1111/j.1753-4887.2008.00136.x

    • Search Google Scholar
    • Export Citation
  • Simó, R., Sáez-López, C., Barbosa-Desongles, A., Hernández, C., & Selva, D.M. (2015). Novel insights in SHBG regulation and clinical implications. Trends in Endocrinology & Metabolism, 26(7), 376–383. doi:10.1016/j.tem.2015.05.001

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Winters, S.J., Gogineni, J., Karegar, M., Scoggins, C., Wunderlich, C.A., Baumgartner, R., & Ghooray, D.T. (2014). Sex hormone-binding globulin gene expression and insulin resistance. The Journal of Clinical Endocrinology & Metabolism, 99(12), E2780–E2788. PubMed ID: 25226295 doi:10.1210/jc.2014-2640

    • Crossref
    • Search Google Scholar
    • Export Citation
All Time Past Year Past 30 Days
Abstract Views 132 132 52
Full Text Views 24 24 8
PDF Downloads 7 7 0