Does Interrupting Prolonged Sitting With 10- or 20-Min Standing Attenuate Postprandial Glycemia and Blood Pressure in Middle-Aged and Older Adults With Type 2 Diabetes?

in Journal of Aging and Physical Activity
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We carried out three types of 2-hr experimental sessions with middle-aged and older adults with Type 2 diabetes in order to examine the acute effect of interrupting prolonged sitting with varying periods of standing on postprandial glycemia and blood pressure (BP): (a) prolonged sitting after breakfast; (b) standing for 10 min, 30 min after breakfast; and (c) standing for 20 min, 30 min after breakfast. Glucose and BP were assessed before and after breakfast. A generalized linear model revealed no significant differences for the incremental area under the curve of glucose between standing for 10 min, 30 min after breakfast, versus prolonged sitting after breakfast (β = –4.5 mg/dl/2 hr, 95% CI [–17.3, 8.4]) and standing for 20 min, 30 min after breakfast, versus prolonged sitting after breakfast (β = 0.9 mg/dl/2 hr, 95% CI [–11.9, 13.7]). There was no difference in area under the curve of systolic and diastolic BP among the sessions. Interrupting prolonged sitting time with 10 or 20 min of standing 30 min after breakfast does not attenuate postprandial glycemia or BP in middle-aged and older adults with Type 2 diabetes.

Freire, Browne, and Costa are with the Graduate Program in Health Sciences, Federal University of Rio Grande do Norte, Natal, Brazil. Silva, de Oliveira, Felipe Martins, and Brito are with the Institute of Physical Education and Sports, Federal University of Ceará, Fortaleza, Brazil. Macêdo and Costa are with the Graduate Program in Physical Education, Federal University of Rio Grande do Norte, Natal, Brazil. Farias-Junior is with the Graduate Program in Psychobiology, Federal University of Rio Grande do Norte, Natal, Brazil.

Costa (ecc@ufrnet.br) is corresponding author.

Supplementary Materials

    • Supplementary Table S1 (PDF 78 KB)
  • American Diabetes Association. (2020). Facilitating behavior change and well-being to improve health outcomes: Standards of medical care in diabetes—2020. Diabetes Care, 43(Suppl. 1), S48.

    • Search Google Scholar
    • Export Citation
  • Bergouignan, A., Latouche, C., Heywood, S., Grace, M.S., Reddy-Luthmoodoo, M., Natoli, A.K., … Kingwell, B.A. (2016). Frequent interruptions of sedentary time modulates contraction- and insulin-stimulated glucose uptake pathways in muscle: Ancillary analysis from randomized clinical trials. Scientific Reports, 6(1), 3204432057. PubMed ID: 27554943 doi:10.1038/srep32044

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Billot, M., Simoneau, E.M., Hoecke, J.Van, & Martin, A. (2010). Age-related relative increases in electromyography activity and torque according to the maximal capacity during upright standing. European Journal of Applied Physiology, 109(4), 669680. PubMed ID: 20213469 doi:10.1007/s00421-010-1397-7

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Borror, A., Zieff, G., Battaglini, C., & Stoner, L. (2018). The effects of postprandial exercise on glucose control in individuals with type 2 diabetes: A systematic review. Sports Medicine, 48(6), 14791491. PubMed ID: 29396781 doi:10.1007/s40279-018-0864-x

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Boutron, I., Altman, D.G., Moher, D., Schulz, K.F., Ravaud, P., & CONSORT NPT Group. (2017). CONSORT statement for randomized trials of nonpharmacologic treatments: A 2017 update and a CONSORT extension for nonpharmacologic trial abstracts. Annals of Internal Medicine, 167(1), 40.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Brazilian Diabetes Society. (2016). Brazilian diabetes society guidelines (2015–2016) (São Paulo; A. Milech, adriana P. Angelucci, A. Golbert, A. Matheus, alexandre J. F. Carrilho, ana C. Ramalho, … A. Sachs, eds.). São Paulo.

    • Search Google Scholar
    • Export Citation
  • Brazilian Diabetes Society. (2017). Brazilian diabetes society guidelines (2017/2018; J.E.P. Oliveira, R.M. Montenegro Junior, & S. Vencio, eds.). São Paulo: Clannad.

    • Search Google Scholar
    • Export Citation
  • Brazilian Society of Cardiology. (2016). 7th Brazilian guideline of arterial hypertension: Chapter 2—Diagnosis and classification. Arquivos Brasileiros de Cardiologia, 107(3).

    • Search Google Scholar
    • Export Citation
  • Browne, R.A.V., Farias-Junior, L.F., Freire, Y.A., Schwade, D., Dantas de Macêdo, G.de A., Montenegro, V.B., … Costa, E.C. (2017). Sedentary occupation workers who meet the physical activity recommendations have a reduced risk for metabolic syndrome. Journal of Occupational and Environmental Medicine, 59(11), 10291033. PubMed ID: 28742767 doi:10.1097/JOM.0000000000001104

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Carter, S., Hartman, Y., Holder, S., Thijssen, D.H., Hopkins, N.D., Hartman, Y., … Hopkins, N. (2017). Sedentary behavior and cardiovascular disease risk: Mediating mechanisms. Exercise and Sport Sciences Reviews, 45(2), 8086. PubMed ID: 28118158 doi:10.1249/JES.0000000000000106

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Ceriello, A., Hanefeld, M., Leiter, L., Monnier, L., Moses, A., Owens, D., … Tuomilehto, J. (2004). Postprandial glucose regulation and diabetic complications. Archives of Internal Medicine, 164(19), 2090. PubMed ID: 15505121 doi:10.1001/archinte.164.19.2090

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Chacko, E. (2014). Timing and intensity of exercise for glucose control. Diabetologia, 57(11), 24252426. PubMed ID: 25056138 doi:10.1007/s00125-014-3339-0

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Cho, N.H., Shaw, J.E., Karuranga, S., Huang, Y., da Rocha Fernandes, J.D., Ohlrogge, A.W., & Malanda, B. (2018). IDF diabetes atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045. Diabetes Research and Clinical Practice, 138, 271281. PubMed ID: 29496507 doi:10.1016/j.diabres.2018.02.023

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Crespo, N.C., Mullane, S.L., Zeigler, Z.S., Buman, M.P., & Gaesser, G.A. (2016). Effects of standing and light-intensity walking and cycling on 24-h glucose. Medicine and Science in Sports and Exercise, 48(12), 25032511. PubMed ID: 27471786 doi:10.1249/MSS.0000000000001062

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Dempsey, P.C., Grace, M.S., & Dunstan, D.W. (2016). Adding exercise or subtracting sitting time for glycaemic control: Where do we stand? Diabetologia. 10.1007/s00125-016-4180-4

    • PubMed
    • Search Google Scholar
    • Export Citation
  • Dempsey, P.C., Larsen, R.N., Dunstan, D.W., Owen, N., & Kingwell, B.A. (2018). Sitting less and moving more implications for hypertension. Hypertension, 72(5), 10371046. PubMed ID: 30354827 doi:10.1161/HYPERTENSIONAHA.118.11190

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Dempsey, P.C., Owen, N., Yates, T.E., Kingwell, B.A., & Dunstan, D.W. (2016). Sitting less and moving more: Improved glycaemic control for type 2 diabetes prevention and management. Current Diabetes Reports, 16(11), 114128. PubMed ID: 27699700 doi:10.1007/s11892-016-0797-4

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Dhatt, G.S., Agarwal, M.M., Othman, Y., & Nair, S.C. (2011). Performance of the roche accu-chek active glucose meter to screen for gestational diabetes mellitus using fasting capillary blood. Diabetes Technology & Therapeutics, 13(12), 12291233. PubMed ID: 21864017 doi:10.1089/dia.2011.0097

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Dunstan, D.W., Kingwell, B.A., Larsen, R., G.N. Healy, Cerin, E., Hamilton, M.T., … Owen, N. (2012). Breaking up prolonged sitting reduces postprandial glucose and insulin responses. Diabetes Care, 35(December 2011), 976983.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Duvivier, B.M.F.M., Schaper, N.C., Hesselink, M.K.C., & Savelberg, H.H.C.M. (2017). Breaking sitting with light activities vs structured exercise : A randomised crossover study demonstrating benefits for glycaemic control and insulin sensitivity in type 2 diabetes. Diabetologia, 60(3), 490498. PubMed ID: 27904925 doi:10.1007/s00125-016-4161-7

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Freckmann, G., Schmid, C., Baumstark, A., Pleus, S., Link, M., & Haug, C. (2012). System accuracy evaluation of 43 blood glucose monitoring systems for self-monitoring of blood glucose according to DIN EN ISO 15197. Journal of Diabetes Science and Technology, 6(5), 10601075. PubMed ID: 23063032 doi:10.1177/193229681200600510

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Freire, Y.A., Macêdo, G.de A.D.de, Browne, R.A.V., Farias-Junior, L.F., Bezerra, Á.D.de L., Fayh, A.P.T., … Costa, E.C. (2019). Effect of breaks in prolonged sitting or low-volume high-intensity interval exercise on markers of metabolic syndrome in adults with excess body fat: A crossover trial. Journal of Physical Activity and Health, 16(9), 727735. PubMed ID: 31310990 doi:10.1123/jpah.2018-0492

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • GBD 2017 Risk Factor Collaborators. (2018). Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990–2017. The Lancet, 392(10159), 19231994. doi:10.1016/S0140-6736(18)32225-6

    • Search Google Scholar
    • Export Citation
  • Hawari, N.S.A., Al-Shayji, I., Wilson, J., & Gill, J.M.R. (2016). Frequency of breaks in sedentary time and postprandial metabolic responses. Medicine & Science in Sports & Exercise, 48(12), 24952502. PubMed ID: 27387291 doi:10.1249/MSS.0000000000001034

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Henson, J., Davies, M.J., Bodicoat, D.H., Edwardson, C.L., Gill, J.M.R., Stensel, D.J., … Dunstan, D.W. (2016). Breaking up prolonged sitting with standing or walking attenuates the postprandial metabolic response in postmenopausal women: A randomized acute study. Diabetes Care, 39(1), 130138. doi:10.2337/dc15-1240

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Honda, H., Igaki, M., Hatanaka, Y., Komatsu, M., Tanaka, S.I., Miki, T., … Hayashi, T. (2016). Stair climbing/descending exercise for a short time decreases blood glucose levels after a meal in participants with type 2 diabetes. BMJ Open Diabetes Research and Care, 4(1), e000232. doi:10.1136/bmjdrc-2016-000232

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Kerr, J., Crist, K., Vital, D.G., Dillon, L., Aden, S.A., Trivedi, M., … Sears, D.D. (2017). Acute glucoregulatory and vascular outcomes of three strategies for interrupting prolonged sitting time in postmenopausal women: A pilot, laboratory-based, randomized, controlled, 4-condition, 4-period crossover trial. PLoS One, 12(11). doi:10.1371/journal.pone.0188544

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Larsen, R.N., Dempsey, P.C., Dillon, F., Grace, M., Kingwell, B.A., Owen, N., & Dunstan, D.W. (2017). Does the type of activity “break” from prolonged sitting differentially impact on postprandial blood glucose reductions? An exploratory analysis. Applied Physiology, Nutrition, and Metabolism, 42(August), 14.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Loh, R., Stamatakis, E., Folkerts, D., Allgrove, J.E., & Moir, H.J. (2019). Effects of interrupting prolonged sitting with physical activity breaks on blood glucose, insulin and triacylglycerol measures: A systematic review and meta-analysis. Sports Medicine, September(50), 295330.

    • Search Google Scholar
    • Export Citation
  • Macêdo, G.A.D., Freire, Y.A., Browne, R.A.V., Farias-Junior, L.F., Cabral, L.L.P., Souto, G.C., … Costa, E.C. (2019). Efeito do tempo sentado prolongado sobre marcadores cardiometabólicos em adultos fisicamente ativos e inativos: um estudo piloto. Revista Brasileira de Atividade Física & Saúde, 23, 111. doi:10.12820/rbafs.23e0060

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Mailey, E.L., Rosenkranz, S.K., Casey, K., & Swank, A. (2016). Comparing the effects of two different break strategies on occupational sedentary behavior in a real world setting: A randomized trial. Preventive Medicine Reports Journal, 4, 423428. doi:10.1016/j.pmedr.2016.08.010

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Malin, S.K., & Stewart, N.R. (2020, August 11). Metformin may contribute to inter-individual variability for glycemic responses to exercise. Frontiers in Endocrinology, Vol. 11. Frontiers Media S.A. doi:10.3389/fendo.2020.00519

    • Crossref
    • Search Google Scholar
    • Export Citation
  • McCarthy, M., Edwardson, C.L., Davies, M.J., Henson, J., Rowlands, A., King, J.A., … Yates, T. (2017). Breaking up sedentary time with seated upper body activity can regulate metabolic health in obese high-risk adults: A randomized crossover trial. Diabetes, Obesity and Metabolism, 19(12), 17321739. PubMed ID: 28544202 doi:10.1111/dom.13016

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Monnier, L., & Colette, C. (2015). Postprandial and basal hyperglycaemia in type 2 diabetes: Contributions to overall glucose exposure and diabetic complications. Diabetes and Metabolism, 41(6), 6S96S15. doi:10.1016/S1262-3636(16)30003-9

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Reynolds, A.N., & Venn, B.J. (2018). The timing of activity after eating affects the glycaemic response of healthy adults: A randomised controlled trial. Nutrients, 10(11). doi:10.3390/nu10111743

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Rodriguez-Hernandez, M., Martin, J.S., Pascoe, D.D., Roberts, M.D., & Wadsworth, D.W. (2018). Multiple short bouts of walking activity attenuate glucose response in obese women. Journal of Physical Activity & Health, 15(4), 279286. doi:10.1123/jpah.2017-0251

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Solomon, T.P.J., Eves, F.F., & Laye, M.J. (2018). Targeting postprandial hyperglycemia with physical activity may reduce cardiovascular disease risk but what should we do, and when is the right time to move? Frontiers in Cardiovascular Medicine, 5(July), 111.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Solomon, T.P.J., Tarry, E., Hudson, C.O., Fitt, A.I., & Laye, M.J. (2019). Immediate post-breakfast physical activity improves interstitial postprandial glycemia: A comparison of different activity-meal timings. European Journal of Physiology, 472(2), 271280. PubMed ID: 31396757 doi:10.1007/s00424-019-02300-4

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Thorsen, I.K., Johansen, M.Y., Pilmark, N.S., Jespersen, N.Z., Brinkløv, C.F., Benatti, F.B., … Ried-Larsen, M. (2019). The effect of frequency of activity interruptions in prolonged sitting on postprandial glucose metabolism: A randomized crossover trial. Metabolism: Clinical and Experimental, 96, 17. doi:10.1016/j.metabol.2019.04.003

    • Crossref
    • Search Google Scholar
    • Export Citation
  • World Health Organization. (1985). Report of a joint FAO/WHO/UNU expert consultation. In Energy and protein requirements. Rome, Italy: World Health Organization.

    • Search Google Scholar
    • Export Citation
  • Yates, T., Edwardson, C.L., Celis-Morales, C., Biddle, S.J.H., Bodicoat, D., Davies, M.J., … Gill, J.M.R. (2020). Metabolic effects of breaking prolonged sitting with standing or light walking in older South Asians and white Europeans: A randomized acute study. Journals of Gerontology—Series A Biological Sciences and Medical Sciences, 75(1), 139146. doi:10.1093/gerona/gly252

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Zeigler, Z.S., Mullane, S.L., Crespo, N.C., Buman, M.P., & Gaesser, G.A. (2016). Effects of standing and light-intensity activity on ambulatory blood pressure. Medicine and Science in Sports and Exercise, 48(2), 175181. PubMed ID: 26285021 doi:10.1249/MSS.0000000000000754

    • Crossref
    • Search Google Scholar
    • Export Citation
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