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Exercise training beneficially moderates the effects of vascular aging. This study compared the efficacy of Peripheral Remodeling through Intermittent Muscular Exercise (PRIME), a novel training regimen, versus aerobic training on hemodynamic profiles in participants ≥70 years at risk for losing functional independence. Seventy-five participants (52 females, age: 76 ± 5 years) were assessed for hemodynamic and vascular function at baseline, after 4 weeks of either PRIME or aerobic training (Phase 1) and again after a further 8 weeks of aerobic and resistance training (Phase 2). Data were analyzed using 2 × 2 repeated-measures analysis of variance models on the change in each dependent variable. PRIME demonstrated reductions in brachial and aortic mean arterial pressure and diastolic blood pressure (p < .05) from baseline after Phase 1, which were sustained throughout Phase 2. Earlier and greater reductions in blood pressure following PRIME support the proposal that peripheral muscular training could beneficial for older individuals commencing an exercise program.

Woessner is with the Institute for Health and Sport, Victoria University, Melbourne, Victoria, Australia. Woessner, VanBruggen, Kraus, and Allen are with the Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA. Welsch is with the John D. Bower School of Population Health, University of Mississippi Medical Center, Jackson, MS, USA. Johannsen and Credeur are with the School of Kinesiology, Louisiana State University, Baton Rouge, LA, USA. Johannsen, Church, and Ravussin are with the Pennington Biomedical Research Center, Baton Rouge, LA, USA. Credeur is with the School of Kinesiology, The University of Southern Mississippi, Hattiesburg, MS, USA. Pieper and Sloane are with the Center for Aging and Human Development, Duke University Medical Center, Durham, NC, USA. Earnest was with the Texas A& M University, College Station, TX, USA, at the time of the study but is now deceased. Ortiz De Zevallos Munoz and Allen are with the Department of Kinesiology, School of Education, and Division of Cardiovascular Medicine, School of Medicine, University of Virginia, Charlottesville, VA, USA.  Allen is also with Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA, USA.

Allen (jason.allen@virginia.edu) is corresponding author.
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