Exercise and Cardioprotection in Coronary Artery Disease: A Pilot Quasi-Experimental Study

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Gareth Thompson
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Gareth W. Davison
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Jacqui Crawford
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Ciara M. Hughes
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Sirtuin-1 is a protein that may orchestrate the cardioprotective effect of exercise by controlling cellular processes. This pilot study assessed the feasibility of performing a quasi-experimental study in this area. Patients with postacute myocardial infarction were recruited across four hospital sites in the United Kingdom. The participants were offered one weekly exercise session at Phase-III and Phase-IV cardiac rehabilitation (CR). Measurements were obtained pre-Phase-III CR (Week 1), post-Phase-III CR (Week 8), and post-Phase-IV CR (Week 22). Twenty-eight patients were recruited (79% male, 100% White, 60.2 ± 10.5 years old). The recruitment rate was not fulfilled (<70% eligible patients recruited; 0.9 participants recruited per week over 30 weeks). The success criteria for dropout rate, adherence rate, and collection of sirtuin-1 measures were satisfied. A large increase in sirtuin-1 (0.14 ± 0.03, d ≥ 0.8) was seen after Phase-III and Phase-IV CR. Collectively, a quasi-experimental study is feasible with a revised recruitment strategy.

Thompson, Crawford, and Hughes are with the Institute of Nursing and Health Research, Ulster University, Newtownabbey, United Kingdom. Davison is with the Sport and Exercise Sciences Research Institute, Ulster University, Newtownabbey, United Kingdom.

Hughes (cm.hughes@ulster.ac.uk) is corresponding author.

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