Effect of High-Intensity Interval Training Versus Moderate-Intensity Aerobic Continuous Training on Galectin-3 Gene Expression in Postmenopausal Women: A Randomized Controlled Trial

in Journal of Aging and Physical Activity
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Galectin-3 is a pro-inflammatory biomarker associated with the pathogenesis of heart failure (HF). Physical-activity reduces the risk of heart-failure by modification of inflammation and fibrosis. The purpose of this study was to compare the effects of 8 weeks of high-intensity interval training (HIIT) versus moderate-intensity aerobic continuous training on a predictive factor of HF in postmenopausal women. Thirty sedentary postmenopausal women were randomly assigned to three groups. The first group performed the HIIT program at 60%–90%, and the second group performed an exercise program at 50%–65% of HR reserve. The control group maintained their normal daily regular physical activity level. The gene expressions of galectin-3 and lipid profiles were measured at the baseline and the end of Week 8. The HIIT and moderate-intensity aerobic continuous training attenuated the gene expression of galectin-3, serum low-density lipoprotein, cholesterol, and triglyceride concentrations and enhanced high-density lipoprotein concentrations. These changes were considerably higher in the HIIT group. Our results show that HIIT is superior to moderate-intensity aerobic continuous training in improving the decrease in HF risk in postmenopausal women.

Keyhani is with the Department of Sport Physiology, Faculty of Physical Education and Sport Sciences, Urmia University, Urmia, Iran. Tartibian is with the Department of Sport Injuries and Corrective Exercise, Faculty of Physical Education and Sport Sciences, Allameh Tabataba’i University, Tehran, Iran. Dabiri is with the Department of Immunology, International Campus, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Teixeira is with the Faculty of Sports Science and Physical Education, University of Coimbra, Coimbra, Portugal.

Keyhani (Keyhanid1368@gmail.com) is corresponding author.
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