Moderate Physical Activity of Music Aerobic Exercise Increases Lymphocyte Counts, Specific Subsets, and Differentiation

in Journal of Physical Activity and Health
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Moderate physical activity has been shown to promote immunity. Different moderate physical activities may have different effects on immunity. This study investigated the impacts of a 12-week regular music aerobic exercise (MAE) program on leukocyte distribution, lymphocyte subsets, and lymphocyte polarization.


The study used a case-control design with pretest and posttest. Forty-seven middle-age women were recruited for this study. Three participants dropped out, 22 completed the 12-week MAE program, and the other 22 participants who had heat-intolerance or limited schedule eligibility were enrolled as the control group without the MAE exercise.


Results showed that the MAE exercise for 12 weeks didn’t change red blood cells or total leukocytes but increased lymphocyte counts. The women in MAE group revealed significant increases (P ≤ 0.01) of CD3CD4, CD3CD8, and CD4CD25 cells, associated with Treg polarization showing enhanced FoxP3 but not T-bet, Gata-3, or RORγT expression (P < .01). The control group without exercise revealed insignificant change of lymphocyte subsets or lymphocyte polarization.


This study shows that MAE increases specific lymphocyte subsets and enhances Treg cell differentiation. It is suggested to encourage moderate physical activity of music aerobic exercise to enhance lymphocyte function of middle-aged women.

Yeh and KD Yang ( are with the Dept of Medical Research & Development, Show Chwan Memorial Hospital, Taiwan. Lai is with the Dept of Medical Research, Kaohsiung Chang Gung Memorial Hospital, Taiwan. Hsiao is with the School of Nursing, Tzu-Hui Institute of Technology, Taiwan. Lin is with the Dept of Nursing, HungKuang University, Taichung, Taiwan. Chuang is the president of Yin Huo Health Association, Taiwan. Y Yang is with the Dept of Laboratory Medicine, Chow Chwan Memorial Hospital at Changhua, Changhua, Taiwan.