Restricted access

Purchase article

USD  $24.95

Student 1 year subscription

USD  $115.00

1 year subscription

USD  $153.00

Student 2 year subscription

USD  $218.00

2 year subscription

USD  $285.00


Autonomic nervous system (ANS) dysfunction and obesity are intrinsically related to each other. In normal-weight subjects physical activity (PA) and fitness are related to cardiovascular autonomic regulation, providing evidence that aerobic training may improve ANS functioning measured by heart rate variability (HRV). The goal of this study was to investigate the association between lifetime PA, aerobic fitness and HRV in obese adults.


Participants included 107 (87 females) volunteers (mean age 44.5 years, median BMI 35.7) who completed health and lifestyle questionnaires and measurements of maximal aerobic performance, anthropometry and 24 h HRV.


In the multivariate linear regression analyses, lifetime physical activity explained 40% of the variance in normal R-R intervals (SDNN). Each 1-category increase in the activity index increased SDNN by 15.4 (P = .009) and 24% of the variance in natural logarithmic value of ultra-low frequency power (P = .050). High measured VO2max explained 45% of the variance in natural logarithmic value of high-frequency power (P = .009) and 25% of the variance in low frequency/high frequency ratio (P < .001).


Lifetime physical activity and aerobic fitness may reduce obesity-related health risks by improving the cardiac autonomic function measured by HRV in obese workingage subjects. This research supports the role of lifetime physical activity in weight management strategies and interventions to reduce obesity-related health risks.

KM Kaikkonen (, H Kaikkonen, and Vanhala are with the Dept of Sports and Exercise Medicine, Oulu Deaconess Institute, Oulu, Finland. R Korpelainen is with Oulu Deaconess Institute and Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland. Tulppo is with the Dept of Exercise and Medical Physiology, Verve, Oulu, Finland. Kallio is with the Dept of Clinical Neurophysiology, Oulu University Hospital, Oulu, Finland. Keinänen-Kiukaanniemi is with the Institute of Health Sciences, Center for Life Course Epidemiology University of Oulu and Oulu University Hospital, Unit of Primary Health Care, Oulu, Finland. JT Korpelainen is with Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.