Gender Differences in C-Reactive Protein and Muscle Strengthening Activity

in Journal of Physical Activity and Health
Restricted access


Few studies have examined the gender differences between C-reactive protein (CRP) and muscle strengthening activity (MSA).


The sample (n = 7533) included U.S. adult (≥20 years of age).participants in the 1999–2004 National Health and Nutrition Examination Survey (NHANES). Created categories of MSA participation included no MSA (referent group), some MSA (≥1 to <2 days/week), and meeting the 2008 Department of Health and Human Services (DHHS) recommendation (≥2 days/week). The dependent variable was elevated CRP (>3 to 10 mg/L).


Analysis revealed significantly lower odds of having elevated CRP for women reporting some MSA (OR 0.64; 95% CI 0.44–0.93, P = .0191). Significantly lower odds of men having elevated CRP was observed in those reporting MSA volumes meeting the DHHS recommendation (OR 0.72; 95% CI 0.59–0.88, P = .0019). Following adjustment for waist circumference (WC) these odds remained significant in men but not women.


These results suggest that WC may mediate the associations between MSA and CRP and this relationship may be stronger in women.

Richardson ( and Churilla are with the Dept of Clinical and Applied Movement Sciences; Johnson is with the Dept of Public Health; University of North Florida, Jacksonville, FL. Katzmarzyk is with the Dept of Population Science, Pennington Biomedical Research Center, Baton Rouge, LA. Ford is with the Dept of Health and Human Services, Centers for Disease Control, Atlanta, GA. Boyer is with the Dept of Kinesiology, Recreation, and Sport Studies, University of Tennessee, Knoxville, TN.