Participation in a Social-Support Physical Activity Intervention Modestly Improves Lipoprotein Cholesterol Distribution Among Postpartum Sedentary Hispanic Women

in Journal of Physical Activity and Health
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Background:

The effects of moderate intensity walking on lipoprotein remodeling in postpartum Hispanic women are unknown.

Methods:

Sedentary postpartum Hispanic women (28.2 ± 5.6 y; BMI = 29.3 ± 3.3 kg/m2) participating in a social support physical activity (PA) intervention, were randomly assigned to a 12-month walking program (walkers; n = 22; target 150 min/wk, moderate intensity) or a control group (nonwalkers; n = 22). Fasting lipids and cholesterol distribution within low-density lipoprotein (LDL) and high-density lipoprotein (HDL) particles were measured at baseline (BL), 6 months, and 12 months.

Results:

Walkers had an 11% increase and nonwalkers a 7% decrease in HDL cholesterol from 6 to 12 months (P = .0367) without an effect on LDL cholesterol. Whereas nonwalkers had virtually no change in mean LDL particle size, walkers had a borderline reduction in LDL size from BL (268.7 ± 4.1 Å) to 6 months (266.9 ± 4.9 Å), followed by a significant increase in size by 12 months (269.7 ± 4.1 Å; P = .011). The proportion of cholesterol in large LDL particles decreased by 15% from BL to 6 months, but subsequently increased 25% by 12 months among walkers; changes among nonwalkers were smaller and in opposite direction (4% and –3%, respectively; P = .0004).

Conclusions:

Participation in the social-support PA intervention resulted in slightly increased HDL cholesterol concentrations and a modest and beneficial shift toward larger, less atherogenic LDL particles.

Vega-López (sonia.vega.lopez@asu.edu), Pignotti, and Ainsworth are with the School of Nutrition and Health Promotion, Arizona State University, Phoenix, AZ; Vega-López is also with the Southwest Interdisciplinary Research Center, Arizona State University, Phoenix, AZ. Keller, Todd, and Nagle Williams are with the College of Nursing and Health Innovation, Arizona State University, Phoenix, AZ; Williams is also with the Southwest Interdisciplinary Research Center, Arizona State University, Phoenix, AZ. Records is with the College of Nursing, University of Missouri, St. Louis, MO. Coonrod is with the Dept of Obstetrics and Gynecology, District Medical Group, Maricopa Integrated Health System, University College of Medicine, Phoenix, AZ. Permana is with the Phoenix Veterans Affairs Health Care System, Phoenix, AZ.