The aim of this study was to investigate the association between lifetime physical activity and risk of lung cancer.
A case-control study was conducted in southern Brazil. Case subjects were recruited from oncology services of 4 hospitals. Control subjects were selected from the same hospitals, but from different services (traumatology and emergency). Both case subjects (n = 81) and control subjects (n = 168) were interviewed using a questionnaire about sociodemographic characteristics, anthropometric information and family history of cancer. Control subjects were matched to case subjects according to sex and age (± 5 years). Detailed information on smoking was collected. Physical activity was measured using the Lifetime Physical Activity Questionnaire.
Of the case subjects, 89% were either current or former smokers; among control subjects, this value was 57%. Participants in the second, third, and fourth quartiles of all-domains physical activity had odds ratios of 0.54 (95% CI, 0.21–1.40), 0.25 (95% CI, 0.08–0.72), and 0.24 (95% CI, 0.07–0.83) for lung cancer, compared with the lowest quartile, after adjusting for confounding. In the fully adjusted models, leisure-time physical activity was not associated with lung cancer risk.
Lifetime all-domains physical activity may reduce the risk of lung cancer.
Brizio (email@example.com), Hallal, and Domingues are with the Postgraduate Program in Physical Education, Federal University of Pelotas, Pelotas, Brazil; and GEEAF—Physical Activity Epidemiology Research Group, Pelotas, Brazil. Hallal is also with the Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil. Lee is with Brigham and Women’s Hospital and Harvard Medical School, Boston, MA.