We aimed to explore the association between self-reported leisure time physical activity (LTPA) and C-reactive protein (CRP) concentrations in men and women with and without impaired glucose tolerance (IGT).
In a cross-sectional study, a random sample (n = 2,816) was examined with an oral glucose tolerance test, CRP and information about LTPA. Those with IGT or normal glucose tolerance (NGT) and CRP value ≤10 mg/L were selected (n = 2,367) for the study.
An inverse association between LTPA and CRP concentrations was observed in the population (P < .001), though, only in men with IGT (P = .023) and in women with NGT. Men with IGT, reporting slight physical activity up to 4 hours a week presented significantly higher CRP concentrations than normoglycemic men (∆0.6 mg/L, P = .004). However, this difference could not be found in men with IGT reporting more intense physical activity (∆0.01 mg/L, P = .944).
Physical inactivity seems to have greater inflammatory consequences for men (vs. women) with IGT. More importantly, although 4 hours of physical activity per week is more than the usual minimum recommendation, an even greater intensity of LTPA appears to be required to limit subclinical inflammation in men with IGT.
Hellgren, Daka, and Lindblad are with the Dept of Primary Health Care, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden. Larsson is with the Dept of Clinical Sciences, Malmö, Lund University, Malmö, Sweden, and the Dept of Primary Health Care, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden. Petzold is with the Center for Applied Biostatistics, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. Jansson is with the Wallenberg Laboratory, Dept of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.