Isotemporal Analysis of the Association of Objectively Measured Physical Activity With Depressive Symptoms: Results From Hispanic Community Health Study/Study of Latinos (HCHS/SOL)

in Journal of Physical Activity and Health
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The burden of depression among Hispanics/Latinos indicates the need to identify factors related to depressive symptoms. This paper examines the relationship of physical activity (PA) and sedentary behavior (SB) with depressive symptoms in Hispanic/Latinos.


The Hispanic Community Health Study / Study of Latinos (HCHS/SOL) is a population-based, cohort study of Hispanic/Latinos in 4 United States metropolitan areas. Objectively measured PA was coded into: sedentary behavior (SB), light-intensity (LPA), moderate-intensity (MPA), and vigorous-intensity (VPA); and the Center for Epidemiological Studies Depression Scale-10 assessed depressive symptoms. Multiple regression analysis utilizing isotemporal substitution, adjusted for relevant covariates, examined PA as predictors of depressive symptoms.


Substitution of 1 hour of SB with VPA resulted in a significant decrease in depressive symptoms (β = –1.215, P = .021). Similar decreases were observed when VPA replaced LPA (β = –1.212, P = .021) and MPA (β = –1.50 P = .034). MPA and LPA were not associated with lower depressive symptoms.


Previous research has focused on the relationship of MVPA on depressive symptoms. Our results suggest these constructs should be examined separately as they may have unique relationships with depressive symptoms. The association of SB with greater depressive symptoms confirms previous reports.

Rethorst is with the Center for Depression Research and Clinical Care, Dept of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX. Moncrieft and Gellman are with the Dept of Psychology, University of Miami, Coral Gables, FL. Arredondo, Buelna, and Castañeda are with the Institute of Behavioral and Community Health, Graduate School of Public Health, San Diego State University, San Diego CA. Daviglus is with the Institute of Minority Health Research, University of Illinois at Chicago, Chicago, IL. Khan is with the Dept of Pediatrics and Family & Social Medicine, Albert Einstein College of Medicine, Bronx, NY. Perreira and Sotres-Alvarez are with the Collaborative Studies Coordinating Center, Dept of Biostatistics Gillings School of Global Public Health, University of North Carolina at Chapel Hill, NC. Stoutenberg is with the Dept of Public Health Sciences, Miller School of Medicine, University of Miami, Miami, FL.

Rethorst ( is corresponding author.