Markers of inflammation are emerging as novel indices of cardiovascular risk. These markers have been shown to alter acutely after intense exercise; however, the effects of more moderate intensity exercise in healthy individuals is not known. Walking forms a cornerstone of physical activity promotion, so the inflammatory response to this exercise merits investigation. This study evaluated the effects of a 45-min walk on C-reactive protein (CRP) and interleukin 6 (IL-6), in sedentary, overweight men.
Fifteen men (49.7 ± 5.9 y) walked for 45 min at 60 to 70% of predicted maximum heart rate. Fasted blood samples were taken prior to and immediately 1 hr and 24 h post-walk.
IL-6 decreased from 1 h post-walk to 24 h post-walk (P < 0.01). No significant changes were observed in CRP.
These findings suggest that 45 min walking at 60 to 70% HRmax-p causes a decrease in IL-6 24 h post-exercise, but does not evoke a significant response in CRP levels.
Murtagh, Boreham, Davison, and Murphy are with the School of Health Sciences, University of Ulster, Newtownabbey, Co. Antrim, BT37 0QB, Northern Ireland, UK. Nevill is with the Research Institute in Healthcare Science, University of Wolverhampton, WV1 1SB, England, UK. Trinick, Duly, and El-Agnaf are with the Ulster Hospital Dundonald, Belfast BT16 1RH Northern Ireland UK.