Impact of Resistance Training Volume on Physical and Perceptual Outcomes of Breast Cancer Survivors Submitted to a Combined Training Program: A Randomized, Single-Blinded Study

in Journal of Physical Activity and Health

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Chaiane Calonego Neuromuscular Assessment Laboratory, Physical Education School, Universidade Federal de Pelotas, Pelotas, RS, Brazil

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Cristine Lima Alberton Neuromuscular Assessment Laboratory, Physical Education School, Universidade Federal de Pelotas, Pelotas, RS, Brazil

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Samarita Beraldo Santagnello Neuromuscular Assessment Laboratory, Physical Education School, Universidade Federal de Pelotas, Pelotas, RS, Brazil

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Gustavo Zaccaria Schaun Neuromuscular Assessment Laboratory, Physical Education School, Universidade Federal de Pelotas, Pelotas, RS, Brazil

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Cristiane Rios Petrarca Hospital Escola, Universidade Federal de Pelota, Pelotas, RS, Brazil

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Daniel Umpierre Department of Public Health, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil

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Elisa Gouvêa Portella Neuromuscular Assessment Laboratory, Physical Education School, Universidade Federal de Pelotas, Pelotas, RS, Brazil

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Luana Siqueira Andrade Neuromuscular Assessment Laboratory, Physical Education School, Universidade Federal de Pelotas, Pelotas, RS, Brazil

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Rochele Barboza Pinheiro Neuromuscular Assessment Laboratory, Physical Education School, Universidade Federal de Pelotas, Pelotas, RS, Brazil

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Maria Laura Brizio Gomes Neuromuscular Assessment Laboratory, Physical Education School, Universidade Federal de Pelotas, Pelotas, RS, Brazil

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Mariana Silva Häfele Neuromuscular Assessment Laboratory, Physical Education School, Universidade Federal de Pelotas, Pelotas, RS, Brazil

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Gabriela Barreto David Neuromuscular Assessment Laboratory, Physical Education School, Universidade Federal de Pelotas, Pelotas, RS, Brazil

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Ronei Silveira Pinto Exercise Research Laboratory, Physical Education School, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil

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João Saldanha Henkin Exercise Research Laboratory, Physical Education School, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil

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Stephanie Santana Pinto Neuromuscular Assessment Laboratory, Physical Education School, Universidade Federal de Pelotas, Pelotas, RS, Brazil

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DOI:
https://doi.org/10.1123/jpah.2022-0097
Keywords:
breast neoplasms; combined training; cancer-related fatigue; quality of life
First Published Online:
23 Jan 2023
In Print:
Volume 20: Issue 3
Page Range:
204–216
Restricted access

Background: To determine the effect of resistance training volume on physical and perceptual outcomes of breast cancer survivors submitted to a combined training program. Design: Randomized single-blinded study. Methods: Nineteen breast cancer survivor women were randomized to a single-set (SS) or a multiple-set (MS) group. Both groups completed an 8-week combined training intervention in which the SS and MS groups performed 1 and 3 sets per resistance exercise, respectively. The following outcomes were assessed preintervention and postintervention: maximal knee extension dynamic strength (1-repetition maximum), quadriceps muscle thickness, peak oxygen uptake, time to exhaustion, cancer-related fatigue, and quality of life. Results: Both interventions increased knee extension 1-repetition maximum (SS: 29.8% [37.5%]; MS: 19.3% [11.8%]), quadriceps muscle thickness (9.4% [4.1%]; 8.9% [5.9%]), and quality of life (4.3% [6.3%]; 7.9% [9.0%]), with no difference between the groups. However, only MS improved cancer-related fatigue (−2.1% [1.7%]) and time to exhaustion (21.3% [14.9%]), whereas peak oxygen uptake remained unchanged in both groups. Conclusions: Cancer-related fatigue and time to exhaustion, improved only in the MS group after the intervention. On the other hand, similar knee extension 1-repetition maximum, quadriceps muscle thickness, and quality of life improvements were observed in breast cancer survivors irrespective of the resistance training volume performed.

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  • 1.

    Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394–424. PubMed ID: 30207593 doi:10.3322/caac.21492

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 2.

    Ferlay J, Colombet M, Soerjomataram I, et al. Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods. Int J Cancer. 2019;144(8):1941–1953. PubMed ID: 30350310 doi:10.1002/ijc.31937

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 3.

    INCA. Instituto Nacional de Câncer José Alencar Gomes da Silva. In: Estimativa 2020: Incidência de Câncer no Brasil. Rio de Janeiro; 2019.

    • Search Google Scholar
    • Export Citation
  • 4.

    DeSantis CE, Bray F, Ferlay J, Lortet-Tieulent J, Anderson BO, Jemal A. International variation in female breast cancer incidence and mortality rates. Cancer Epidemiol Prev Biomarkers. 2015;24(10):1495–1506. doi:10.1158/1055-9965.EPI-15-0535

    • Search Google Scholar
    • Export Citation
  • 5.

    Harrington S, Padua D, Battaglini C, et al. Comparison of shoulder flexibility, strength, and function between breast cancer survivors and healthy participants. J cancer Surviv. 2011;5(2):167–174. PubMed ID: 21225372 doi:10.1007/s11764-010-0168-0

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 6.

    Santagnello SB, Martins FM, de Oliveira Junior GN, de Sousa JdFR, Nomelini RS, Murta EFC, Orsatti FL. Resistance training–induced gains in muscle strength and power mediate the improvement in walking speed in middle-aged women who are breast cancer survivors. J Strength & Cond Res. Published online March 24, 2021. doi:10.1519/JSC.0000000000004020

    • Search Google Scholar
    • Export Citation
  • 7.

    Irwin ML. Benefits of aerobic and resistance exercise for cancer survivors. In: Ulrich CM, et al, (Eds.), Exercise, Energy Balance, and Cancer (vol. 6). New York: Springer; 2013:199–213.

    • Search Google Scholar
    • Export Citation
  • 8.

    Jones LW, Liang Y, Pituskin EN, et al. Effect of exercise training on peak oxygen consumption in patients with cancer: a meta-analysis. Oncologist. 2011;16(1):112. PubMed ID: 21212429 doi:10.1634/theoncologist.2010-0197

    • Search Google Scholar
    • Export Citation
  • 9.

    Weis J. Cancer-related fatigue: prevalence, assessment and treatment strategies. Expert Rev Pharmacoeconomics Outcomes Res. 2011;11(4):441–446. doi:10.1586/erp.11.44

    • Search Google Scholar
    • Export Citation
  • 10.

    Berger AM, Mooney K, Alvarez-Perez A, et al. Cancer-related fatigue, version 2.2015. J Natl Compr Cancer Netw. 2015;13(8):1012–1039. doi:10.6004/jnccn.2015.0122

    • Search Google Scholar
    • Export Citation
  • 11.

    Pagola I, Morales JS, Alejo LB, et al. Concurrent exercise interventions in breast cancer survivors with cancer-related fatigue. Int J Sports Med. 2020;41(11):790–797. PubMed ID: 32599641

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 12.

    Schneider CM, Hsieh CC, Sprod LK, Carter SD, Hayward R. Effects of supervised exercise training on cardiopulmonary function and fatigue in breast cancer survivors during and after treatment. Cancer Interdiscip Int J Am Cancer Soc. 2007;110(4):918–925. doi:10.1002/cncr.22862

    • Search Google Scholar
    • Export Citation
  • 13.

    Fairman CM, Zourdos MC, Helms ER, Focht BC. A scientific rationale to improve resistance training prescription in exercise oncology. Sports Med. 2017;47(8):1457–1465. doi:10.1007/s40279-017-0673-7

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 14.

    Kraemer WJ, Ratamess NA. Fundamentals of resistance training: progression and exercise prescription. Med Sci Sport Exerc. 2004;36(4):674–688. doi:10.1249/01.MSS.0000121945.36635.61

    • Search Google Scholar
    • Export Citation
  • 15.

    Radaelli R, Botton CE, Wilhelm EN, et al. Low- and high-volume strength training induces similar neuromuscular improvements in muscle quality in elderly women. Exp Gerontol. 2013;48(8):710–716. PubMed ID: 23603619 doi:10.1016/j.exger.2013.04.003

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 16.

    Radaelli R, Wilhelm EN, Botton CE, et al. Effects of single vs. multiple-set short-term strength training in elderly women. Age. 2014;36(6):9720. doi:10.1007/s11357-014-9720-6

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 17.

    Lombardi VP. Beginning Weight Training: The Safe and Effective Way. WCB/McGraw-Hill; 1989.

  • 18.

    Kumagai K, Abe T, Brechue WF, Ryushi T, Takano S, Mizuno M. Sprint performance is related to muscle fascicle length in male 100-m sprinters. J Appl Physiol. 2000;88(3):811–816. PubMed ID: 10710372 doi:10.1152/jappl.2000.88.3.811

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 19.

    Korhonen MT, Mero AA, Alen M, et al. Biomechanical and skeletal muscle determinants of maximum running speed with aging. Med Sci Sport Exerc. 2009;41(4):844–856. doi:10.1249/MSS.0b013e3181998366

    • Search Google Scholar
    • Export Citation
  • 20.

    Chilibeck PD, Stride D, Farthing JP, Burke DG. Effect of creatine ingestion after exercise on muscle thickness in males and females. Med Sci Sport Exerc. 2004;36(10):1781–1788. doi:10.1249/01.MSS.0000142301.70419.C6

    • Search Google Scholar
    • Export Citation
  • 21.

    Schaun GZ, Bamman MM, Andrade LS, et al. High-velocity resistance training mitigates physiological and functional impairments in middle-aged and older adults with and without mobility-limitation. GeroScience. 2022;44:1175–1197. doi:10.1007/s11357-022-00520-8

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 22.

    Jackson AS, Pollock ML, Ward ANN. Generalized equations for predicting body density of women. Med Sci Sports Exerc. 1980;12(3):175–181. PubMed ID: 7402053 doi:10.1249/00005768-198023000-00009

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 23.

    Wasserman K, Whipp BJ, Koyl SN, Beaver WL. Anaerobic threshold and respiratory gas exchange during exercise. J Appl Physiol. 1973;35(2):236–243. PubMed ID: 4723033 doi:10.1152/jappl.1973.35.2.236

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 24.

    Mota DDCF, Pimenta CAM, Piper BF. Fatigue in Brazilian cancer patients, caregivers, and nursing students: a psychometric validation study of the piper fatigue scale-revised. Support Care Cancer. 2009;17(6):645–652. PubMed ID: 18987899 doi:10.1007/s00520-008-0518-x

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 25.

    Piper BF, Dibble SL, Dodd MJ, Weiss MC, Slaughter RE, Paul SM. The revised piper fatigue scale: psychometric evaluation in women with breast cancer. Oncol Nurs Forum. 1998;25:677–684.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 26.

    Berger AM, Abernethy AP, Atkinson A, et al. NCCN clinical practice guidelines cancer-related fatigue. J Natl Compr Cancer Netw JNCCN. 2010;8(8):904–931. PubMed ID: 20870636 doi:10.6004/jnccn.2010.0067

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 27.

    Michels FAS, Latorre M, Maciel MS. Validity and reliability of the FACT-B+ 4 quality of life questionnaire specific for breast cancer and comparison of IBCSG, EORTC-BR23 and FACT-B+ 4 questionnaires. Cad Saúde Colet. 2012;20(3):321–328.

    • Search Google Scholar
    • Export Citation
  • 28.

    Pinto S, Portella E, Alberton C, et al. Effects of different volumes of combined training in breast cancer survivors: a pilot study: 1548 Board #310 May 30 10:30 AM–12:00 PM. Med Sci Sport Exerc. 2019;51(6)(suppl 1):427. doi:10.1249/01.mss.0000561779.97589.5b

    • Search Google Scholar
    • Export Citation
  • 29.

    Cohen J. (1998). Statistical Power Analysis for the Behavioral Sciences (2nd ed.). Routledge. doi:10.4324/9780203771587

  • 30.

    Lopez P, Galvão DA, Taaffe DR, et al. Resistance training in breast cancer patients undergoing primary treatment: a systematic review and meta-regression of exercise dosage. Breast Cancer. 2021;28(1):16–24. PubMed ID: 32815096 doi:10.1007/s12282-020-01147-3

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 31.

    Christensen JF, Jones LW, Andersen JL, Daugaard G, Rorth M, Hojman P. Muscle dysfunction in cancer patients. Ann Oncol. 2014;25(5):947–958. PubMed ID: 24401927 doi:10.1093/annonc/mdt551

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 32.

    Villaseñor A, Ballard-Barbash R, Baumgartner K, et al. Prevalence and prognostic effect of sarcopenia in breast cancer survivors: the HEAL Study. J Cancer Surviv. 2012;6(4):398–406. PubMed ID: 23054848 doi:10.1007/s11764-012-0234-x

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 33.

    Ahmed RL, Thomas W, Yee D, Schmitz KH. Randomized controlled trial of weight training and lymphedema in breast cancer survivors. J Clin Oncol. 2006;24(18):2765–2772. PubMed ID: 16702582 doi:10.1200/JCO.2005.03.6749

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 34.

    Schmitz KH, Ahmed RL, Hannan PJ, Yee D. Safety and efficacy of weight training in recent breast cancer survivors to alter body composition, insulin, and insulin-like growth factor axis proteins. Cancer Epidemiol Prev Biomarkers. 2005;14(7):1672–1680. doi:10.1158/1055-9965.EPI-04-0736

    • Search Google Scholar
    • Export Citation
  • 35.

    Ohira T, Schmitz KH, Ahmed RL, Yee D. Effects of weight training on quality of life in recent breast cancer survivors: the weight training for breast cancer survivors (WTBS) study. Cancer Interdiscip Int J Am Cancer Soc. 2006;106(9):2076–2083. doi:10.1002/cncr.21829

    • Search Google Scholar
    • Export Citation
  • 36.

    Musanti R. A study of exercise modality and physical self-esteem in breast cancer survivors. Med Sci Sport Exerc. 2012;44(2):352–361. doi:10.1249/MSS.0b013e31822cb5f2

    • Search Google Scholar
    • Export Citation
  • 37.

    Schmidt T, Weisser B, Jonat W, Baumann FT, Mundhenke C. Gentle strength training in rehabilitation of breast cancer patients compared to conventional therapy. Anticancer Res. 2012;32(8):3229–3233.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 38.

    Simonavice E, Liu P-Y, Ilich JZ, Kim J-S, Arjmandi B, Panton LB. The effects of a 6-month resistance training and dried plum consumption intervention on strength, body composition, blood markers of bone turnover, and inflammation in breast cancer survivors. Appl Physiol Nutr Metab. 2014;39(6):730–739. PubMed ID: 24869977 doi:10.1139/apnm-2013-0281

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 39.

    Madzima TA, Ormsbee MJ, Schleicher EA, Moffatt RJ, Panton LB. Effects of resistance training and protein supplementation in breast cancer survivors. Med Sci Sports Exerc. 2017;49(7):1283–1292. PubMed ID: 28252552 doi:10.1249/MSS.0000000000001250

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 40.

    Baracos VE, Arribas L. Sarcopenic obesity: hidden muscle wasting and its impact for survival and complications of cancer therapy. Ann Oncol. 2018;29(suppl 2):ii1–ii9. doi:10.1093/annonc/mdx810

    • Search Google Scholar
    • Export Citation
  • 41.

    Brown JC, Schmitz KH. Weight lifting and appendicular skeletal muscle mass among breast cancer survivors: a randomized controlled trial. Breast Cancer Res Treat. 2015;151(2):385–392. PubMed ID: 25935584 doi:10.1007/s10549-015-3409-0

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 42.

    Dieli-Conwright CM, Courneya KS, Demark-Wahnefried W, et al. Effects of aerobic and resistance exercise on metabolic syndrome, sarcopenic obesity, and circulating biomarkers in overweight or obese survivors of breast cancer: a randomized controlled trial. J Clin Oncol. 2018;36(9):875. PubMed ID: 29356607 doi:10.1200/JCO.2017.75.7526

    • Search Google Scholar
    • Export Citation
  • 43.

    Schmitz KH, Ahmed RL, Troxel A, et al. Weight lifting in women with breast-cancer–related lymphedema. N Engl J Med. 2009;361(7):664–673. PubMed ID: 19675330 doi:10.1056/NEJMoa0810118

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 44.

    Schmitz KH, Ahmed RL, Troxel AB, et al. Weight lifting for women at risk for breast cancer–related lymphedema: a randomized trial. JAMA. 2010;304(24):2699–2705. PubMed ID: 21148134 doi:10.1001/jama.2010.1837

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 45.

    Lopez P, Taaffe DR, Newton RU, Buffart LM, Galvão DA. What is the minimal dose for resistance exercise effectiveness in prostate cancer patients? Systematic review and meta-analysis on patient-reported outcomes. Prostate Cancer Prostatic Dis. 2021;24(2):465–481. PubMed ID: 33219369 doi:10.1038/s41391-020-00301-4

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 46.

    Campbell KL, Winters-Stone KM, Wiskemann J, et al. Exercise guidelines for cancer survivors: consensus statement from international multidisciplinary roundtable. Med Sci Sport Exerc. 2019;51(11):2375–2390. doi:10.1249/MSS.0000000000002116

    • Search Google Scholar
    • Export Citation
  • 47.

    Bardwell WA, Profant J, Casden DR, et al. The relative importance of specific risk factors for insomnia in women treated for early-stage breast cancer. Psychooncology. 2008;17(1):9–18. PubMed ID: 17428006 doi:10.1002/pon.1192

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 48.

    Pirl WF. Evidence report on the occurrence, assessment, and treatment of depression in cancer patients. JNCI Monogr. 2004;2004(32):32–39. doi:10.1093/jncimonographs/lgh026

    • Search Google Scholar
    • Export Citation
  • 49.

    Greenlee H, DuPont-Reyes MJ, Balneaves LG, et al. Clinical practice guidelines on the evidence-based use of integrative therapies during and after breast cancer treatment. CA Cancer J Clin. 2017;67(3):194–232. PubMed ID: 28436999 doi:10.3322/caac.21397

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 50.

    Sweegers MG, Altenburg TM, Chinapaw MJ, et al. Which exercise prescriptions improve quality of life and physical function in patients with cancer during and following treatment? A systematic review and meta-analysis of randomised controlled trials. Br J Sports Med. 2018;52(8):505–513. PubMed ID: 28954800 doi:10.1136/bjsports-2017-097891

    • PubMed
    • Search Google Scholar
    • Export Citation
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