The mediating effect of peripheral narrowing in the negative life event stress (N-LES)/athletic injury relationship was investigated. LES and other psychosocial variables were measured, and peripheral vision was assessed in nonstressful (practice day) and stressful (game day) sport situations. Results showed that total LES, N-LES, and psychological coping skills significantly contributed to the prediction of the occurrence of athletic injury. Additionally, psychological coping skills buffered the N-LES/athletic injury relationship. Peripheral narrowing during stress significantly mediated 8.1% of the N-LES/athletic injury relationship. The findings support the predictions of the model of stress and injury, provide evidence for peripheral narrowing as a mechanism in the LES/athletic injury relationship, and suggest directions for future research examining mediating effects in the model of stress and injury.