rs6295 [C]-Allele Protects Against Depressive Mood in Elderly Endurance Athletes

Click name to view affiliation

Helmuth Haslacher Medical University of Vienna

Search for other papers by Helmuth Haslacher in
Current site
Google Scholar
PubMed
Close
,
Matthias Michlmayr Medical University of Vienna

Search for other papers by Matthias Michlmayr in
Current site
Google Scholar
PubMed
Close
,
Delgerdalai Batmyagmar Medical University of Vienna

Search for other papers by Delgerdalai Batmyagmar in
Current site
Google Scholar
PubMed
Close
,
Thomas Perkmann Medical University of Vienna

Search for other papers by Thomas Perkmann in
Current site
Google Scholar
PubMed
Close
,
Elisabeth Ponocny-Seliger Empirical Research, Vienna

Search for other papers by Elisabeth Ponocny-Seliger in
Current site
Google Scholar
PubMed
Close
,
Vanessa Scheichenberger General Hospital of Vienna

Search for other papers by Vanessa Scheichenberger in
Current site
Google Scholar
PubMed
Close
,
Thomas M. Scherzer Sanatorium Hera, Vienna

Search for other papers by Thomas M. Scherzer in
Current site
Google Scholar
PubMed
Close
,
Sonja Nistler Sanatorium Hera, Vienna

Search for other papers by Sonja Nistler in
Current site
Google Scholar
PubMed
Close
,
Alexander Pilger Medical University of Vienna

Search for other papers by Alexander Pilger in
Current site
Google Scholar
PubMed
Close
,
Peter Dal-Bianco Medical University of Vienna

Search for other papers by Peter Dal-Bianco in
Current site
Google Scholar
PubMed
Close
,
Johann Lehrner Medical University of Vienna

Search for other papers by Johann Lehrner in
Current site
Google Scholar
PubMed
Close
,
Lukas Pezawas Medical University of Vienna

Search for other papers by Lukas Pezawas in
Current site
Google Scholar
PubMed
Close
,
Oswald F. Wagner Medical University of Vienna

Search for other papers by Oswald F. Wagner in
Current site
Google Scholar
PubMed
Close
, and
Robert Winker Sanatorium Hera, Vienna

Search for other papers by Robert Winker in
Current site
Google Scholar
PubMed
Close
Restricted access

A single nucleotide variant within the promoter of the 5-hydroxytryptamine1A (5HT1A) receptor, rs6295, is part of a binding site for the transcription factor NUDR (nuclear-DEAF-1-related). We aimed to ascertain whether the rs6295 mediates the effect of exercise on depressive mood in elderly endurance athletes. We prospectively enrolled 55 elderly athletes (marathon runners/bicyclists) and 58 controls. In a controlled, univariate model, an interaction between the [C]-allele and physical activity indicated that only among athletes, the variant resulting in an imperfect NUDR binding site was associated with a lower depression score. Hence, athletes presented with a significantly lower relative risk of achieving a suspicious depression score among carriers of at least one [C]-allele. Our results suggest that the positive effect of physical exercise on depressive mood might be mediated by the 5HT1A receptor and the extent of this protective effect seems to be enhanced by the [C]-allele of the rs6295 variant.

Helmuth Haslacher, Matthias Michlmayr, Thomas Perkmann, and Oswald F. Wagner are with the Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria. Delgerdalai Batmyagmar is with the Department of Public Health, Medical University of Vienna, Vienna, Austria. Elisabeth Ponocny-Seliger is with Empirical Research, Vienna, Austria. Vanessa Scheichenberger is with the Day Clinic of Psychosomatic Medicine, Department of Child and Adolescent Medicine, General Hospital of Vienna, Austria. Thomas M. Scherzer, Sonja Nistler, and Robert Winker are with the Health and Prevention Center, Sanatorium Hera, Vienna, Austria. Alexander Pilger is with the Division of Occupational Medicine, Medical University of Vienna, Austria. Peter Dal-Bianco and Johann Lehrner are with the Department of Neurology, Medical University of Vienna, Vienna, Austria. Lukas Pezawas is with the Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.

Address author correspondence to Helmuth Haslacher at helmuth.haslacher@meduniwien.ac.at.