Reflex sympathetic dystrophy (RSD) is a debilitating and recalcitrant condition that has bewildered the medical community for decades. This article briefly reviews the pathophysiology of RSD and describes the clinical presentation and management of patients suffering from RSD. The case study describes the clinical and electrodiagnostic findings of a patient with RSD following arthroscopic surgery on the knee. The medical and physical interventions rendered in this case are described.