Context: Athletes at the highest levels appear to be most affected by sport-related injuries and suffer both physiologically and psychologically. Established models of psychological responses to injury, however, do not offer a comprehensive explanation based on posttraumatic stress disorder (PTSD), although some studies suggest that injuries may be interpreted as traumatic. Studies also suggest that perceived self-efficacy may be a mediator of PTSD development. Objective: This study examines the psychological sequelae experienced by high-level athletes as a result of sport-related injuries based on a PTSD–self-efficacy framework. Design: A cross-sectional survey design was used. Participants: Forty-six athletes (30 males and 16 females) from 4 different sports were conveniently sampled and completed a questionnaire battery assessing injury characteristics, trauma sequelae, and self-efficacy. Main Outcome Measures: Present injury status, PTSD symptomatology, and general self-efficacy. Results: Injury was found to be associated with elevated levels of PTSD symptomatology. The presence of injury was a significant predictor of general PTSD and, specifically, hyperarousal symptoms; however, general self-efficacy was not found to predict trauma-related symptoms. There were indications, however, that self-efficacy beliefs may affect injury-related factors. Conclusions: This research highlights the presence of PTSD-related psychological dysfunction associated with sport injury, and further uncovers the possible impacts of self-efficacy beliefs in managing the stress of injury. These findings highlight the need for psychological support as injured athletes undergo rehabilitation.