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Exercise remains greatly underutilized in clinical practice for reasons that are only partly understood. This critical review situates the problem within the broader political and economic context. It focuses on depression, the leading cause of disability worldwide, and the processes that followed the inclusion of exercise as a treatment option in clinical practice guidelines in the British National Health Service. The review highlights previously unaddressed phenomena, including antiexercise lobbying by primary care physicians and efforts to present the evidence for the antidepressant effects of exercise as weak, nonexistent, or methodologically flawed. Notably, the field of kinesiology remained silent while these processes unfolded. This information suggests that the path from research evidence to implementation in clinical settings remains dependent on factors beyond the amount and quality of research evidence. The review underscores the need to vigilantly monitor, critically appraise, and actively participate in the clinical research literature and the development of guidelines.
The author (ekkekaki@iastate.edu) is with the Dept. of Kinesiology, Iowa State University, Ames, IA, USA.
Adlington, K. (2018). Pop a million happy pills? Antidepressants, nuance, and the media. British Medical Journal, 360, k1069. PubMed ID: 29523579 doi:10.1136/bmj.k1069
American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). Washington, DC: Author. doi:10.1176/appi.books.9780890425596
American Psychological Association Guideline Development Panel for the Treatment of Depressive Disorders. (2019). Clinical practice guideline for the treatment of depression across three age cohorts. Washington, DC: American Psychological Association.
AuYoung, M., Linke, S.E., Pagoto, S., Buman, M.P., Craft, L.L., Richardson, C.R., … Sheinfeld Gorin, S. (2016). Integrating physical activity in primary care practice. American Journal of Medicine, 129(10), 1022–1029. doi:10.1016/j.amjmed.2016.02.008
Baghai, T.C., Blier, P., Baldwin, D.S., Bauer, M., Goodwin, G.M., Fountoulakis, K.N., … Möller, H.-J. (2011). General and comparative efficacy and effectiveness of antidepressants in the acute treatment of depressive disorders: A report by the WPA section of pharmacopsychiatry. European Archives of Psychiatry and Clinical Neuroscience, 261(suppl 3), 207–245. doi:10.1007/s00406-011-0259-6
Bailey, A.P., Hetrick, S.E., Rosenbaum, S., Purcell, R., & Parker, A.G. (2018). Treating depression with physical activity in adolescents and young adults: A systematic review and meta-analysis of randomised controlled trials. Psychological Medicine, 48(7), 1068–1083. PubMed ID: 28994355 doi:10.1017/S0033291717002653
Barbui, C., Cipriani, A., Patel, V., Ayuso-Mateos, J.L., & van Ommeren, M. (2011). Efficacy of antidepressants and benzodiazepines in minor depression: Systematic review and meta-analysis. British Journal of Psychiatry, 198(1), 11–16. PubMed ID: 21200071 doi:10.1192/bjp.bp.109.076448
Bartram, M. (2019). Expanding access to psychotherapy in Canada: Building on achievements in Australia and the United Kingdom. Healthcare Management Forum, 32(2), 63–67. PubMed ID: 30700162 doi:10.1177/0840470418818581
Baxter, H., Winder, R., Chalder, M., Wright, C., Sherlock, S., Haase, A., … Lewis, G. (2010). Physical activity as a treatment for depression: The TREAD randomised trial protocol. Trials, 11(1), 105. PubMed ID: 21073712 doi:10.1186/1745-6215-11-105
Bell, S., Clark, D.M., Knapp, M., Layard, R., Meacher, M.C., Priebe, S., … Wright, B. (2006). The depression report: A new deal for depression and anxiety disorders. London, UK: Mental Health Policy Group, Centre for Economic Performance, London School of Economics and Political Science.
Binnie, J. (2015). Do you want therapy with that? A critical account of working within IAPT. Mental Health Review Journal, 20(2), 79–83. doi:10.1108/MHRJ-11-2014-0044
Blumenthal, J.A., Babyak, M.A., Doraiswamy, P.M., Watkins, L., Hoffman, B.M., Barbour, K.A., … Sherwood, A. (2007). Exercise and pharmacotherapy in the treatment of major depressive disorder. Psychosomatic Medicine, 69(7), 587–596. PubMed ID: 17846259 doi:10.1097/PSY.0b013e318148c19a
Blumenthal, J.A., Sherwood, A., Babyak, M.A., Watkins, L.L., Smith, P.J., Hoffman, B.M., … Hinderliter, A.L. (2012). Exercise and pharmacological treatment of depressive symptoms in patients with coronary heart disease: Results from the UPBEAT (Understanding the Prognostic Benefits of Exercise and Antidepressant Therapy) study. Journal of the American College of Cardiology, 60(12), 1053–1063. PubMed ID: 22858387 doi:10.1016/j.jacc.2012.04.040
Bridle, C., Spanjers, K., Patel, S., Atherton, N.M., & Lamb, S.E. (2012). Effect of exercise on depression severity in older people: Systematic review and meta-analysis of randomised controlled trials. British Journal of Psychiatry, 201(3), 180–185. PubMed ID: 22945926 doi:10.1192/bjp.bp.111.095174
Busch, A.M., Ciccolo, J.T., Puspitasari, A.J., Nosrat, S., Whitworth, J.W., & Stults-Kolehmainen, M. (2016). Preferences for exercise as a treatment for depression. Mental Health and Physical Activity, 10, 68–72. PubMed ID: 27453730 doi:10.1016/j.mhpa.2015.12.004
Cameron, I.M., Cardy, A., Crawford, J.R., du Toit, S.W., Hay, S., Lawton, K., … Reid, I.C. (2011). Measuring depression severity in general practice: Discriminatory performance of the PHQ-9, HADS-D, and BDI-II. British Journal of General Practice, 61(588), e419–e426. PubMed ID: 21722450 doi:10.3399/bjgp11X583209
Carneiro, L.F., Mota, M.P., Schuch, F., Deslandes, A., & Vasconcelos-Raposo, J. (2017). Portuguese and Brazilian guidelines for the treatment of depression: Exercise as medicine. Revista Brasileira de Psiquiatria, 40(2), 210–211. PubMed ID: 28876380 doi:10.1590/1516-4446-2017-2272
Carney, R.M., & Freedland, K.E. (2017). Depression and coronary heart disease. Nature Reviews Cardiology, 14(3), 145–155. PubMed ID: 27853162 doi:10.1038/nrcardio.2016.181
Chalder, M., Wiles, N.J., Campbell, J., Hollinghurst, S.P., Haase, A.M., Taylor, A.H., … Lewis, G. (2012). Facilitated physical activity as a treatment for depressed adults: Randomised controlled trial. British Medical Journal, 344, e2758. PubMed ID: 22674921 doi:10.1136/bmj.e2758
Chekroud, A.M., & Trugerman, A. (2019). The opportunity for exercise to improve population mental health. JAMA Psychiatry, 76(11), 1206–1207. doi:10.1001/jamapsychiatry.2019.2282
Cherbuin, N., Kim, S., & Anstey, K.J. (2015). Dementia risk estimates associated with measures of depression: A systematic review and meta-analysis. BMJ Open, 5(12), e008853. PubMed ID: 26692556 doi:10.1136/bmjopen-2015-008853
Cipriani, A., Furukawa, T.A., Salanti, G., Chaimani, A., Atkinson, L.Z., Ogawa, Y., … Geddes, J.R. (2018). Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: A systematic review and network meta-analysis. The Lancet, 391(10128), 1357–1366. doi:10.1016/S0140-6736(17)32802-7
Cipriani, A., Salanti, G., Furukawa, T.A., Egger, M., Leucht, S., Ruhe, H.G., … Geddes, J.R. (2018). Antidepressants might work for people with major depression: Where do we go from here? Lancet Psychiatry, 5(6), 461–463. doi:10.1016/S2215-0366(18)30133-0
Clark, D.M. (2018). Realizing the mass public benefit of evidence-based psychological therapies: The IAPT program. Annual Review of Clinical Psychology, 14(1), 159–183. PubMed ID: 29350997 doi:10.1146/annurev-clinpsy-050817-084833
Clark, D.M., Layard, R., Smithies, R., Richards, D.A., Suckling, R., & Wright, B. (2009). Improving access to psychological therapy: Initial evaluation of two UK demonstration sites. Behaviour Research and Therapy, 47(11), 910–920. PubMed ID: 19647230 doi:10.1016/j.brat.2009.07.010
Cooney, G., Dwan, K., & Mead, G. (2014). Exercise for depression. Journal of the American Medical Association, 311(23), 2432–2433. PubMed ID: 24938566 doi:10.1001/jama.2014.4930
Cooney, G.M., Dwan, K., Greig, C.A., Lawlor, D.A., Rimer, J., Waugh, F.R., … Mead, G.E. (2013). Exercise for depression. Cochrane Database of Systematic Reviews, 9, CD004366. doi:10.1002/14651858.cd004366.pub6
Cooper, M., & Shurlock, J. (2015). Is general practice engaged with physical activity promotion? British Journal of General Practice, 65(640), 573. PubMed ID: 26500302 doi:10.3399/bjgp15X687289
Cosgrove, L., Bursztajn, H.J., Erlich, D.R., Wheeler, E.E., & Shaughnessy, A.F. (2013). Conflicts of interest and the quality of recommendations in clinical guidelines. Journal of Evaluation in Clinical Practice, 19(4), 674–681. PubMed ID: 23731207 doi:10.1111/jep.12016
Cosgrove, L., Erlich, D., & Shaughnessy, A.F. (2019). No magic pill: A prescription for enhanced shared decision-making for depression treatment. Journal of the American Board of Family Medicine, 32(1), 6–9. PubMed ID: 30610135 doi:10.3122/jabfm.2019.01.180182
Cosgrove, L., Shaughnessy, A.F., Wheeler, E.E., Austad, K.E., Kirsch, I., & Bursztajn, H.J. (2012). The American Psychiatric Association’s guideline for major depressive disorder: A commentary. Psychotherapy and Psychosomatics, 81(3), 186–188. PubMed ID: 22433532 doi:10.1159/000335523
Cosgrove, L., & Vaswani, A. (2019). The influence of pharmaceutical companies and restoring integrity to psychiatric research and practice. In S. Steingard (Ed.), Critical psychiatry: Controversy and clinical implications (pp. 71–96). Cham, Switzerland: Springer. doi:10.1007/978-3-030-02732-2_3
Cromarty, P., Drummond, A., Francis, T., Watson, J., & Battersby, M. (2016). NewAccess for depression and anxiety: Adapting the UK improving access to psychological therapies program across Australia. Australasian Psychiatry, 24(5), 489–492. PubMed ID: 27034440 doi:10.1177/1039856216641310
Cuijpers, P., Turner, E.H., Mohr, D.C., Hofmann, S.G., Andersson, G., Berking, M., & Coyne, J. (2014). Comparison of psychotherapies for adult depression to pill placebo control groups: A meta-analysis. Psychological Medicine, 44(4), 685–695. doi:10.1017/S0033291713000457
Cuijpers, P., Vogelzangs, N., Twisk, J., Kleiboer, A., Li, J., & Penninx, B.W. (2014). Comprehensive meta-analysis of excess mortality in depression in the general community versus patients with specific illnesses. American Journal of Psychiatry, 171(4), 453–462. doi:10.1176/appi.ajp.2013.13030325
Curbach, J., Apfelbacher, C., Knoll, A., Herrmann, S., Szagun, B., & Loss, J. (2018). Physicians’ perspectives on implementing the prevention scheme “Physical Activity on Prescription”: Results of a survey in Bavaria. Zeitschrift fur Evidenz, Fortbildung und Qualitat im Gesundheitswesen, 131–132, 66–72. doi:10.1016/j.zefq.2018.02.001
Dalal, F. (2019). CBT, the cognitive behavioural tsunami: Managerialism, politics and the corruptions of science. New York, NY: Routledge.
Daley, A., & Jolly, K. (2012). Exercise to treat depression. British Medical Journal, 344, e3181. PubMed ID: 22674923 doi:10.1136/bmj.e3181
De Camargo, K.R., Jr. (2012). How to identify science being bent: The tobacco industry’s fight to deny second-hand smoking health hazards as an example. Social Science and Medicine, 75(7), 1230–1235. doi:10.1016/j.socscimed.2012.03.057
Din, N.U., Moore, G.F., Murphy, S., Wilkinson, C., & Williams, N.H. (2015). Health professionals’ perspectives on exercise referral and physical activity promotion in primary care: Findings from a process evaluation of the National Exercise Referral Scheme in Wales. Health Education Journal, 74(6), 743–757. PubMed ID: 26527835 doi:10.1177/0017896914559785
Dorow, M., Löbner, M., Pabst, A., Stein, J., & Riedel-Heller, S.G. (2018). Preferences for depression treatment including internet-based interventions: Results from a large sample of primary care patients. Frontiers in Psychiatry, 9, 181. PubMed ID: 29867605 doi:10.3389/fpsyt.2018.00181
Dumesnil, H., Cortaredona, S., Verdoux, H., Sebbah, R., Paraponaris, A., & Verger, P. (2012). General practitioners’ choices and their determinants when starting treatment for major depression: A cross sectional, randomized case-vignette survey. PLoS One, 7(12), e52429. PubMed ID: 23272243 doi:10.1371/journal.pone.0052429
Ebrahim, S., Bance, S., Athale, A., Malachowski, C., & Ioannidis, J.P. (2016). Meta-analyses with industry involvement are massively published and report no caveats for antidepressants. Journal of Clinical Epidemiology, 70, 155–163. PubMed ID: 26399904 doi:10.1016/j.jclinepi.2015.08.021
Ekkekakis, P. (2015). Honey, I shrunk the pooled SMD! Guide to critical appraisal of systematic reviews and meta-analyses using the Cochrane review on exercise for depression as example. Mental Health and Physical Activity, 8(1), 21–36doi:10.1016/j.mhpa.2014.12.001
Ekkekakis, P. (2019). Physical activity and mental health in the era of evidence-based medicine. In T. S. Horn & A. L. Smith (Eds.), Advances in sport and exercise psychology (4th ed., pp. 353–373). Champaign, IL: Human Kinetics.
Ekkekakis, P., Hartman, M.E., & Ladwig, M.A. (2018). Mass media representations of the evidence as a possible deterrent to recommending exercise for the treatment of depression: Lessons five years after the extraordinary case of TREAD-UK. Journal of Sports Sciences, 36(16), 1860–1871. PubMed ID: 29350586 doi:10.1080/02640414.2018.1423856
Ekkekakis, P., Hartman, M.E., & Ladwig, M.A. (2019). Conceptual foundations of exercise psychology: Facilitators, inhibitors, and a road map toward establishing societal relevance. In M.H. Anshel (Ed.), APA handbook of sport and exercise psychology (Vol. 2, pp. 27–56). Washington, DC: American Psychological Association. doi:10.1037/0000124-002
Ekkekakis, P., & Murri, M.B. (2017). Exercise as antidepressant treatment: Time for the transition from trials to clinic? General Hospital Psychiatry, 49, A1–A5. doi:10.1016/j.genhosppsych.2017.11.004
Ernst, E., & Lee, M.S. (2008). A trial design that generates only “positive” results. Journal of Postgraduate Medicine, 54(3), 214–216. doi:10.4103/0022-3859.41806
Every-Palmer, S., & Howick, J. (2014). How evidence-based medicine is failing due to biased trials and selective publication. Journal of Evaluation in Clinical Practice, 20(6), 908–914. PubMed ID: 24819404 doi:10.1111/jep.12147
Farah, W.H., Alsawas, M., Mainou, M., Alahdab, F., Farah, M.H., Ahmed, A.T., … LeBlanc, A. (2016). Non-pharmacological treatment of depression: A systematic review and evidence map. Evidence-Based Medicine, 21(6), 214–221. PubMed ID: 27836921 doi:10.1136/ebmed-2016-110522
Fountoulakis, K.N., & Möller, H.-J. (2011). Efficacy of antidepressants: A re-analysis and re-interpretation of the Kirsch data. International Journal of Neuropsychopharmacology, 14(3), 405–412. PubMed ID: 20800012 doi:10.1017/S1461145710000957
Fountoulakis, K.N., & Möller, H.-J. (2012). Antidepressant drugs and the response in the placebo group: The real problem lies in our understanding of the issue. Journal of Psychopharmacology, 26(5), 744–750. PubMed ID: 21926425 doi:10.1177/0269881111421969
Fountoulakis, K.N., Samara, M.T., & Siamouli, M. (2014). Burning issues in the meta-analysis of pharmaceutical trials for depression. Journal of Psychopharmacology, 28(2), 106–117. PubMed ID: 24043723 doi:10.1177/0269881113504014
Fountoulakis, K.N., Veroniki, A.A., Siamouli, M., & Möller, H.J. (2013). No role for initial severity on the efficacy of antidepressants: Results of a multi-meta-analysis. Annals of General Psychiatry, 12(1), 26. PubMed ID: 23941527 doi:10.1186/1744-859X-12-26
Fournier, J.C., DeRubeis, R.J., Hollon, S.D., Dimidjian, S., Amsterdam, J.D., Shelton, R.C., & Fawcett, J. (2010). Antidepressant drug effects and depression severity: A patient-level meta-analysis. Journal of the American Medical Association, 303(1), 47–53. PubMed ID: 20051569 doi:10.1001/jama.2009.1943
Freeman, M.P., Fava, M., Lake, J., Trivedi, M.H., Wisner, K.L., & Mischoulon, D. (2010). Complementary and alternative medicine in major depressive disorder: the American Psychiatric Association task force report. Journal of Clinical Psychiatry, 71(6), 669–681. PubMed ID: 20573326 doi:10.4088/JCP.10cs05959blu
Friedrich, M.J. (2017). Depression is the leading cause of disability around the world. Journal of the American Medical Association, 317(15), 1517. PubMed ID: 28418491 doi:10.1001/jama.2017.3826
Gandré, C., Rosenberg, S., Coldefy, M., & Or, Z. (2019). Experimenting locally with a stepped-care approach for the treatment of mild to moderate mental disorders in France: Challenges and opportunities. Health Policy, 123(11), 1021–1027. PubMed ID: 31495560 doi:10.1016/j.healthpol.2019.08.006
Gaynes, B.N., Rush, A.J., Trivedi, M.H., Wisniewski, S.R., Spencer, D., & Fava, M. (2008). The STAR*D study: Treating depression in the real world. Cleveland Clinic Journal of Medicine, 75(1), 57–66. PubMed ID: 18236731 doi:10.3949/ccjm.75.1.57
Geddes, J.R., & Cipriani, A. (2015). Time to abandon placebo control in pivotal phase III trials? World Psychiatry, 14(3), 306–307. PubMed ID: 26407783 doi:10.1002/wps.20246
Gelenberg, A.J., Freeman, M.P., Markowitz, J.C., Rosenbaum, J.F., Thase, M.E., Trivedi, M.H., & Van Rhoads, R.S. (2010). Practice guideline for the treatment of patients with major depressive disorder (3rd ed.). Arlington, VA: American Psychiatric Association.
Glowacki, K., Weatherson, K., & Faulkner, G. (2019). Barriers and facilitators to health care providers’ promotion of physical activity for individuals with mental illness: A scoping review. Mental Health and Physical Activity, 16, 152–168. doi:10.1016/j.mhpa.2018.10.006
Grabovac, I., Stefanac, S., Smith, L., Haider, S., Cao, C., Jackson, S.E., … Yang, L. (2020). Association of depression symptoms with receipt of healthcare provider advice on physical activity among US adults. Journal of Affective Disorders, 262, 304–309. PubMed ID: 31733918 doi:10.1016/j.jad.2019.11.023
Gratzer, D., & Goldbloom, D. (2016). Making evidence-based psychotherapy more accessible in Canada. Canadian Journal of Psychiatry, 61(10), 618–623. PubMed ID: 27310234 doi:10.1177/0706743716642416
Greenblatt, D.J., Harmatz, J.S., & Shader, R.I. (2018). Update on psychotropic drug prescribing in the United States: 2014–2015. Journal of Clinical Psychopharmacology, 38(1), 1–4. PubMed ID: 29215384 doi:10.1097/JCP.0000000000000831
Griffiths, S., & Steen, S. (2013). Improving Access to Psychological Therapies (IAPT) programme: Scrutinising IAPT cost estimates to support effective commissioning. Journal of Psychological Therapies in Primary Care, 2(2), 142–156.
Gyani, A., Shafran, R., Layard, R., & Clark, D.M. (2013). Enhancing recovery rates: Lessons from year one of IAPT. Behaviour Research and Therapy, 51(9), 597–606. PubMed ID: 23872702 doi:10.1016/j.brat.2013.06.004
Hallgren, M., Stubbs, B., Vancampfort, D., Lundin, A., Jääkallio, P., & Forsell, Y. (2017). Treatment guidelines for depression: Greater emphasis on physical activity is needed. European Psychiatry, 40, 1–3. PubMed ID: 27837666 doi:10.1016/j.eurpsy.2016.08.011
Harrison, R.A., McNair, F., & Dugdill, L. (2005). Access to exercise referral schemes: A population based analysis. Journal of Public Health, 27(4), 326–330. PubMed ID: 16207736 doi:10.1093/pubmed/fdi048
Harrop, C., Read, J., Geekie, J., & Renton, J. (2018). An independent audit of pharma influence in public mental health trusts in England. Ethical Human Psychology and Psychiatry, 20(3), 156–168. doi:10.1891/1559-4343.20.3.156
Härter, M., Klesse, C., Bermejo, I., Schneider, F., & Berger, M. (2010). Unipolar depression: Diagnostic and therapeutic recommendations from the current S3/National Clinical Practice Guideline. Deutsches Arzteblatt International, 107(40), 700–708. PubMed ID: 21031129 doi:10.3238/arztebl.2010.0700
Hébert, E.T., Caughy, M.O., & Shuval, K. (2012). Primary care providers’ perceptions of physical activity counselling in a clinical setting: A systematic review. British Journal of Sports Medicine, 46(9), 625–631. PubMed ID: 22711796 doi:10.1136/bjsports-2011-090734
Heinzel, S., Lawrence, J.B., Kallies, G., Rapp, M.A., & Heissel, A. (2015). Using exercise to fight depression in older adults: A systematic review and meta-analysis. GeroPsych: The Journal of Gerontopsychology and Geriatric Psychiatry, 28(4), 149–162. doi:10.1024/1662-9647/a000133
Hengartner, M.P. (2018). What is the threshold for a clinical minimally important drug effect? BMJ Evidence-Based Medicine, 23(6), 225–227. doi:10.1136/bmjebm-2018-111056
Hengartner, M.P., Jakobsen, J.C., Sørensen, A., & Plöderl, M. (2020). Efficacy of new-generation antidepressants assessed with the Montgomery-Asberg Depression Rating Scale, the gold standard clinician rating scale: A meta-analysis of randomised placebo-controlled trials. PLoS One, 15(2), e0229381. PubMed ID: 32101579 doi:10.1371/journal.pone.0229381
Hengartner, M.P., & Plöderl, M. (2018). Statistically significant antidepressant-placebo differences on subjective symptom-rating scales do not prove that the drugs work: Effect size and method bias matter! Frontiers in Psychiatry, 9, 517. PubMed ID: 30386270 doi:10.3389/fpsyt.2018.00517
Hengartner, M.P., Plöderl, M., Braillon, A., Jakobsen, J.C., & Gluud, C. (2020). Sertraline in primary care: Comments on the PANDA trial. Lancet Psychiatry, 7(1), 17. PubMed ID: 31860449 doi:10.1016/S2215-0366(19)30381-5
Hepgul, N., King, S., Amarasinghe, M., Breen, G., Grant, N., Grey, N., … Cleare, A.J. (2016). Clinical characteristics of patients assessed within an Improving Access to Psychological Therapies (IAPT) service: Results from a naturalistic cohort study (Predicting Outcome Following Psychological Therapy; PROMPT). BMC Psychiatry, 16(1), 52. PubMed ID: 26920578 doi:10.1186/s12888-016-0736-6
Hermens, M.L., Muntingh, A., Franx, G., van Splunteren, P.T., & Nuyen, J. (2014). Stepped care for depression is easy to recommend, but harder to implement: Results of an explorative study within primary care in the Netherlands. BMC Family Practice, 15(1), 5. PubMed ID: 24400701 doi:10.1186/1471-2296-15-5
Hieronymus, F., Emilsson, J.F., Nilsson, S., & Eriksson, E. (2016). Consistent superiority of selective serotonin reuptake inhibitors over placebo in reducing depressed mood in patients with major depression. Molecular Psychiatry, 21(4), 523–530. PubMed ID: 25917369 doi:10.1038/mp.2015.53
Holland, R. (2009). Improving access to psychological therapies: The intention. London Journal of Primary Care, 2(1), 50–51. PubMed ID: 26042167 doi:10.1080/17571472.2009.11493243
Horder, J., Matthews, P., & Waldmann, R. (2011). Placebo, Prozac and PLoS: Significant lessons for psychopharmacology. Journal of Psychopharmacology, 25(10), 1277–1288. PubMed ID: 20571143 doi:10.1177/0269881110372544
Houle, J., Villaggi, B., Beaulieu, M.D., Lespérance, F., Rondeau, G., & Lambert, J. (2013). Treatment preferences in patients with first episode depression. Journal of Affective Disorders, 147(1–3), 94–100. PubMed ID: 23167975 doi:10.1016/j.jad.2012.10.016
Huijg, J.M., Gebhardt, W.A., Verheijden, M.W., van der Zouwe, N., de Vries, J.D., Middelkoop, B.J., & Crone, M.R. (2015). Factors influencing primary health care professionals’ physical activity promotion behaviors: A systematic review. International Journal of Behavioral Medicine, 22(1), 32–50. PubMed ID: 24788314 doi:10.1007/s12529-014-9398-2
Iacobucci, G. (2013). Better care for elderly will replace some “box ticking” under new GP contract. British Medical Journal, 347, f6909. PubMed ID: 24246841 doi:10.1136/bmj.f6909
Ioannidis, J.P. (2008). Effectiveness of antidepressants: An evidence myth constructed from a thousand randomized trials? Philosophy, Ethics, and Humanities in Medicine, 3(1), 14. PubMed ID: 18505564 doi:10.1186/1747-5341-3-14
Ioannidis, J.P. (2016). Evidence-based medicine has been hijacked: A report to David Sackett. Journal of Clinical Epidemiology, 73, 82–86. PubMed ID: 26934549 doi:10.1016/j.jclinepi.2016.02.012
Jakobsen, J.C., Katakam, K.K., Schou, A., Hellmuth, S.G., Stallknecht, S.E., Leth-Møller, K., … Gluud, C. (2017). Selective serotonin reuptake inhibitors versus placebo in patients with major depressive disorder: A systematic review with meta-analysis and trial sequential analysis. BMC Psychiatry, 17(1), 58. PubMed ID: 28178949 doi:10.1186/s12888-016-1173-2
Jesulola, E., Micalos, P., & Baguley, I.J. (2018). Understanding the pathophysiology of depression: From monoamines to the neurogenesis hypothesis model: Are we there yet? Behavioural Brain Research, 341, 79–90. PubMed ID: 29284108 doi:10.1016/j.bbr.2017.12.025
Jonas, S., & Phillips, E.M. (2009). ACSM’s exercise is medicine: A clinician’s guide to exercise prescription. Philadelphia, PA: Lippincott Williams & Wilkins.
Kantor, E.D., Rehm, C.D., Haas, J.S., Chan, A.T., & Giovannucci, E.L. (2015). Trends in prescription drug use among adults in the United States from 1999–2012. Journal of the American Medical Association, 314(17), 1818–1831. PubMed ID: 26529160 doi:10.1001/jama.2015.13766
Kendrick, T., Dowrick, C., McBride, A., Howe, A., Clarke, P., Maisey, S., … Smith, P.W. (2009). Management of depression in UK general practice in relation to scores on depression severity questionnaires: Analysis of medical record data. British Medical Journal, 338, b750. PubMed ID: 19299475 doi:10.1136/bmj.b750
Kessler, D., Lewis, G., Kaur, S., Wiles, N., King, M., Weich, S., … Peters, T.J. (2009). Therapist-delivered internet psychotherapy for depression in primary care: A randomised controlled trial. The Lancet, 374(9690), 628–634. PubMed ID: 19700005 doi:10.1016/S0140-6736(09)61257-5
Kessler, R.C., Merikangas, K.R., & Wang, P.S. (2007). Prevalence, comorbidity, and service utilization for mood disorders in the United States at the beginning of the twenty-first century. Annual Review of Clinical Psychology, 3(1), 137–158. PubMed ID: 17716051 doi:10.1146/annurev.clinpsy.3.022806.091444
Khan, A., & Brown, W.A. (2015). Antidepressants versus placebo in major depression: An overview. World Psychiatry, 14(3), 294–300. PubMed ID: 26407778 doi:10.1002/wps.20241
Kirsch, I. (2010). The emperor’s new drugs: Exploding the antidepressant myth. New York, NY: Basic Books.
Kirsch, I., Deacon, B.J., Huedo-Medina, T.B., Scoboria, A., Moore, T.J., & Johnson, B.T. (2008). Initial severity and antidepressant benefits: A meta-analysis of data submitted to the Food and Drug Administration. PLoS Medicine, 5(2), e45. PubMed ID: 18303940 doi:10.1371/journal.pmed.0050045
Kobori, O., Nakazato, M., Yoshinaga, N., Shiraishi, T., Takaoka, K., Nakagawa, A., … Shimizu, E. (2014), Transporting Cognitive Behavioral Therapy (CBT) and the Improving Access to Psychological Therapies (IAPT) project to Japan: Preliminary observations and service evaluation in Chiba. Journal of Mental Health Training, Education and Practice, 9(3), 155–166. doi:10.1108/JMHTEP-10-2013-0033
Kok, R.M., & Reynolds, C.F., 3rd. (2017). Management of depression in older adults: A review. Journal of the American Medical Association, 317(20), 2114–2122. PubMed ID: 28535241 doi:10.1001/jama.2017.5706
Krogh, J., Hjorthøj, C., Speyer, H., Gluud, C., & Nordentoft, M. (2017). Exercise for patients with major depression: A systematic review with meta-analysis and trial sequential analysis. BMJ Open, 7(9), e014820. PubMed ID: 28928174 doi:10.1136/bmjopen-2016-014820
Kvam, S., Kleppe, C.L., Nordhus, I.H., & Hovland, A. (2016). Exercise as a treatment for depression: A meta-analysis. Journal of Affective Disorders, 202, 67–86. PubMed ID: 27253219 doi:10.1016/j.jad.2016.03.063
Laynard, R., Clark, D., Knapp, M., & Mayraz, G. (2007). Cost-benefit analysis of psychological therapy. National Institute Economic Review, 202(1), 90–98. doi:10.1177/0027950107086171
Leijon, M.E., Bendtsen, P., Nilsen, P., Ekberg, K., & Ståhle, A. (2008). Physical activity referrals in Swedish primary health care: Prescriber and patient characteristics, reasons for prescriptions, and prescribed activities. BMC Health Services Research, 8(1), 201. PubMed ID: 18828898 doi:10.1186/1472-6963-8-201
Lewis, G. (2012). Authors’ reply to Davies and colleagues, Donnelly, and Pilling and Anderson. British Medical Journal, 345, e4500. doi:10.1136/bmj.e4500
Lewis, G., Duffy, L., Ades, A., Amos, R., Araya, R., Brabyn, S., … Lewis, G. (2019). The clinical effectiveness of sertraline in primary care and the role of depression severity and duration (PANDA): A pragmatic, double-blind, placebo-controlled randomised trial. Lancet Psychiatry, 6(11), 903–914. PubMed ID: 31543474 doi:10.1016/S2215-0366(19)30366-9
Lion, A., Vuillemin, A., Thornton, J.S., Theisen, D., Stranges, S., & Ward, M. (2019). Physical activity promotion in primary care: A Utopian quest? Health Promotion International, 34(4), 877–886. PubMed ID: 29893846 doi:10.1093/heapro/day038
Lobelo, F., Rohm Young, D., Sallis, R., Garber, M.D., Billinger, S.A., Duperly, J., … Joy, E.A. (2018). Routine assessment and promotion of physical activity in healthcare settings: A scientific statement from the American Heart Association. Circulation, 137(18), e495–e522. PubMed ID: 29618598 doi:10.1161/CIR.0000000000000559
Luck-Sikorski, C., Stein, J., Heilmann, K., Maier, W., Kaduszkiewicz, H., Scherer, M., … Riedel-Heller, S.G. (2017). Treatment preferences for depression in the elderly. International Psychogeriatrics, 29(3), 389–398. PubMed ID: 27890036 doi:10.1017/S1041610216001885
MacAuley, D. (2006). Physical activity may be good for you but we are not the key players. British Journal of General Practice, 56(532), 888. PubMed ID: 17132366
Malhi, G.S., Bassett, D., Boyce, P., Bryant, R., Fitzgerald, P.B., Fritz, K., … Singh, A.B. (2015). Royal Australian and New Zealand College of Psychiatrists clinical practice guidelines for mood disorders. Australian and New Zealand Journal of Psychiatry, 49(12), 1087–1206. PubMed ID: 26643054 doi:10.1177/0004867415617657
Marks, D.F. (2018). IAPT under the microscope. Journal of Health Psychology, 23(9), 1131–1135. PubMed ID: 30008263 doi:10.1177/1359105318781872
McAllister-Williams, R.H. (2008). Do antidepressants work? A commentary on 'Initial severity and antidepressant benefits: A meta-analysis of data submitted to the Food and Drug Administration’ by Kirsch et al. Evidence-Based Mental Health, 11(3), 66–68. PubMed ID: 18669671 doi:10.1136/ebmh.11.3.66
McCrone, P. (2013). IAPT is probably not cost-effective. British Journal of Psychiatry, 202(5), 383. PubMed ID: 23637111 doi:10.1192/bjp.202.5.383
McPherson, S., & Sunkin, M. (2020). The Dobson-Rawlins pact and the National Institute for Health and Care Excellence: Impact of political independence on scientific and legal accountability. British Journal of Psychiatry, 216(4), 231–234. PubMed ID: 31138337 doi:10.1192/bjp.2019.121
Mead, G.E. (2012). Physical activity as a treatment for depressed adults. Journal of the Royal College of Physicians of Edinburgh, 42(4), 325. PubMed ID: 23240120 doi:10.4997/JRCPE.2012.410
Mercier, A., Auger-Aubin, I., Lebeau, J.P., Schuers, M., Boulet, P., Hermil, J.L., … Peremans, L. (2013). Evidence of prescription of antidepressants for non-psychiatric conditions in primary care: An analysis of guidelines and systematic reviews. BMC Family Practice, 14(1), 55. PubMed ID: 23641784 doi:10.1186/1471-2296-14-55
Mitchell, C., Dwyer, R., Hagan, T., & Mathers, N. (2011). Impact of the QOF and the NICE guideline in the diagnosis and management of depression: A qualitative study. British Journal of General Practice, 61(586), e279–e289. PubMed ID: 21619752 doi:10.3399/bjgp11X572472
Moberly, T. (2018). The pharma deals that CCGs fail to declare. British Medical Journal, 360, j5915. PubMed ID: 29298768 doi:10.1136/bmj.j5915
Mojtabai, R., & Olfson, M. (2011). Proportion of antidepressants prescribed without a psychiatric diagnosis is growing. Health Affairs, 30(8), 1434–1442. PubMed ID: 21821561 doi:10.1377/hlthaff.2010.1024
Möller, H.-J. (2008). Isn’t the efficacy of antidepressants clinically relevant? A critical comment on the results of the meta-analysis by Kirsch et al. 2008. European Archives of Psychiatry and Clinical Neuroscience, 258(8), 451–455. doi:10.1007/s00406-008-0836-5
Morres, I.D., Hatzigeorgiadis, A., Stathi, A., Comoutos, N., Arpin-Cribbie, C., Krommidas, C., & Theodorakis, Y. (2019). Aerobic exercise for adult patients with major depressive disorder in mental health services: A systematic review and meta-analysis. Depression and Anxiety, 36(1), 39–53. PubMed ID: 30334597 doi:10.1002/da.22842
Mukuria, C., Brazier, J., Barkham, M., Connell, J., Hardy, G., Hutten, R., … Parry, G. (2013). Cost-effectiveness of an improving access to psychological therapies service. British Journal of Psychiatry, 202(3), 220–227. PubMed ID: 23307921 doi:10.1192/bjp.bp.111.107888
Mulinari, S., & Ozieranski, P. (2018). Disclosure of payments by pharmaceutical companies to healthcare professionals in the UK: Analysis of the Association of the British Pharmaceutical Industry’s Disclosure UK database, 2015 and 2016 cohorts. BMJ Open, 8(10), e023094. PubMed ID: 30344175 doi:10.1136/bmjopen-2018-023094
Mura, G., Moro, M.F., Patten, S.B., & Carta, M.G. (2014). Exercise as an add-on strategy for the treatment of major depressive disorder: A systematic review. CNS Spectrums, 19(6), 496–508. PubMed ID: 24589012 doi:10.1017/S1092852913000953
Naci, H., & Ioannidis, J.P. (2015). Comparative effectiveness of exercise and drug interventions on mortality outcomes: Metaepidemiological study. British Journal of Sports Medicine, 49(21), 1414–1422. PubMed ID: 26476429 doi:10.1136/bjsports-2015-f5577rep
Naci, H., Salcher-Konrad, M., Dias, S., Blum, M.R., Sahoo, S.A., Nunan, D., & Ioannidis, J. (2019). How does exercise treatment compare with antihypertensive medications? A network meta-analysis of 391 randomised controlled trials assessing exercise and medication effects on systolic blood pressure. British Journal of Sports Medicine, 53(14), 859–869. PubMed ID: 30563873 doi:10.1136/bjsports-2018-099921
National Collaborating Centre for Mental Health and National Institute for Clinical Excellence. (2004). Depression: Management of depression in primary and secondary care (National Clinical Practice Guideline Number 23). London, UK: National Institute for Clinical Excellence.
National Collaborating Centre for Mental Health and National Institute for Health and Clinical Excellence. (2010). The treatment and management of depression in adults (updated edition). London, UK: The British Psychological Society and The Royal College of Psychiatrists.
Netz, Y. (2017). Is the comparison between exercise and pharmacologic treatment of depression in the clinical practice guideline of the American College of Physicians evidence-based? Frontiers in Pharmacology, 8, 257. PubMed ID: 28555108 doi:10.3389/fphar.2017.00257
Olfson, M., Blanco, C., & Marcus, S.C. (2016). Treatment of adult depression in the United States. JAMA Internal Medicine, 176(10), 1482–1491. PubMed ID: 27571438 doi:10.1001/jamainternmed.2016.5057
Olfson, M., & Marcus, S.C. (2009). National patterns in antidepressant medication treatment. Archives of General Psychiatry, 66(8), 848–856. PubMed ID: 19652124 doi:10.1001/archgenpsychiatry.2009.81
Organization for Economic Cooperation and Development. (2019). Health at a glance 2019: OECD indicators. Paris, France: OECD Publishing. doi:10.1787/4dd50c09-en
Ormel, J., Spinhoven, P., De Vries, Y., Cramer, A., Siegle, G., Bockting, C., & Hollon, S. (2020). The antidepressant standoff: Why it continues and how to resolve it. Psychological Medicine, 50(2), 177–186. PubMed ID: 31779735 doi:10.1017/S0033291719003295
Orrow, G., Kinmonth, A.L., Sanderson, S., & Sutton, S. (2012). Effectiveness of physical activity promotion based in primary care: Systematic review and meta-analysis of randomised controlled trials. British Medical Journal, 344, e1389. PubMed ID: 22451477 doi:10.1136/bmj.e1389
Otte, C., Gold, S.M., Penninx, B.W., Pariante, C.M., Etkin, A., Fava, M., … Schatzberg, A.F. (2016). Major depressive disorder. Nature Reviews Disease Primers, 2(1), 16065. PubMed ID: 27629598 doi:10.1038/nrdp.2016.65
Ozieranski, P., Csanadi, M., Rickard, E., Tchilingirian, J., & Mulinari, S. (2019). Analysis of pharmaceutical industry payments to UK health care organizations in 2015. JAMA Network Open, 2(6), e196253. PubMed ID: 31225896 doi:10.1001/jamanetworkopen.2019.6253
Parker, G., & Crawford, J. (2007). Judged effectiveness of differing antidepressant strategies by those with clinical depression. Australian and New Zealand Journal of Psychiatry, 41(1), 32–37. PubMed ID: 17464679 doi:10.1080/00048670601057726
Penninx, B.W. (2017). Depression and cardiovascular disease: Epidemiological evidence on their linking mechanisms. Neuroscience and Biobehavioral Reviews, 74(Pt B), 277–286. PubMed ID: 27461915 doi:10.1016/j.neubiorev.2016.07.003
Persson, G., Ovhed, I., & Hansson, E.E. (2010). Simplified routines in prescribing physical activity can increase the amount of prescriptions by doctors, more than economic incentives only: An observational intervention study. BMC Research Notes, 3(1), 304. PubMed ID: 21078135 doi:10.1186/1756-0500-3-304
Pigott, H.E. (2011). STAR*D: A tale and trail of bias. Ethical Human Psychology and Psychiatry, 13(1), 6–28. doi:10.1891/1559-4343.13.1.6
Pigott, H.E. (2015). The STAR*D trial: It is time to reexamine the clinical beliefs that guide the treatment of major depression. Canadian Journal of Psychiatry, 60(1), 9–13. PubMed ID: 25886544 doi:10.1177/070674371506000104
Pratt, L.A., Brody, D.J., & Gu, Q. (2011). Antidepressant use in persons aged 12 and over: United States, 2005–2008. National Center for Health Statistics Data Brief, 76, 1–8. PubMed ID: 22617183
Qaseem, A., Barry, M.J., & Kansagara, D. (2016). Nonpharmacologic versus pharmacologic treatment of adult patients with major depressive disorder: A clinical practice guideline from the American College of Physicians. Annals of Internal Medicine, 164(5), 350–359. PubMed ID: 26857948 doi:10.7326/M15-2570
Radhakrishnan, M., Hammond, G., Jones, P.B., Watson, A., McMillan-Shields, F., & Lafortune, L. (2013). Cost of improving Access to Psychological Therapies (IAPT) programme: An analysis of cost of session, treatment and recovery in selected Primary Care Trusts in the East of England region. Behaviour Research and Therapy, 51(1), 37–45. PubMed ID: 23178677 doi:10.1016/j.brat.2012.10.001
Raue, P.J., Weinberger, M.I., Sirey, J.A., Meyers, B.S., & Bruce, M.L. (2011). Preferences for depression treatment among elderly home health care patients. Psychiatric Services, 62(5), 532–537. PubMed ID: 21532080 doi:10.1176/ps.62.5.pss6205_0532
Ravindran, A.V., Balneaves, L.G., Faulkner, G., Ortiz, A., McIntosh, D., Morehouse, R.L., … Parikh, S.V. (2016). Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 clinical guidelines for the management of adults with major depressive disorder: Section 5. Complementary and alternative medicine treatments. Canadian Journal of Psychiatry, 61(9), 576–587. PubMed ID: 27486153 doi:10.1177/0706743716660290
Read, J., & Williams, J. (2018). Adverse effects of antidepressants reported by a large international cohort: Emotional blunting, suicidality, and withdrawal effects. Current Drug Safety, 13(3), 176–186. PubMed ID: 29866014 doi:10.2174/1574886313666180605095130
Rhyner, K.T., & Watts, A. (2016). Exercise and depressive symptoms in older adults: A systematic meta-analytic review. Journal of Aging and Physical Activity, 24(2), 234–246. PubMed ID: 26372020 doi:10.1123/japa.2015-0146.
Richards, D.A., Bower, P., Pagel, C., Weaver, A., Utley, M., Cape, J., … Vasilakis, C. (2012). Delivering stepped care: An analysis of implementation in routine practice. Implementation Science, 7(1), 3. PubMed ID: 22248385 doi:10.1186/1748-5908-7-3
Rising, K., Bacchetti, P., & Bero, L. (2008). Reporting bias in drug trials submitted to the Food and Drug Administration: Review of publication and presentation. PLoS Medicine, 5(11), e217. PubMed ID: 19067477 doi:10.1371/journal.pmed.0050217
Rowley, N., Mann, S., Steele, J., Horton, E., & Jimenez, A. (2018). The effects of exercise referral schemes in the United Kingdom in those with cardiovascular, mental health, and musculoskeletal disorders: A preliminary systematic review. BMC Public Health, 18(1), 949. PubMed ID: 30068338 doi:10.1186/s12889-018-5868-9
Rowley, N., Steele, J., Wade, M., Copeland, R.J., Mann, S., Liguori, G., … Jimenez, A. (2020). Are exercise referral schemes associated with an increase in physical activity? Observational findings using individual patient data meta-analysis from the National Referral Database. Journal of Physical Activity and Health, 17(6), 621–631. doi:10.1123/jpah.2019-0435
Rush, A.J., Trivedi, M.H., Wisniewski, S.R., Nierenberg, A.A., Stewart, J.W., Warden, D., … Fava, M. (2006). Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: A STAR*D report. American Journal of Psychiatry, 163(11), 1905–1917. PubMed ID: 17074942 doi:10.1176/ajp.2006.163.11.1905
Schuch, F.B., Vancampfort, D., Richards, J., Rosenbaum, S., Ward, P.B., & Stubbs, B. (2016). Exercise as a treatment for depression: A meta-analysis adjusting for publication bias. Journal of Psychiatric Research, 77, 42–51. PubMed ID: 26978184 doi:10.1016/j.jpsychires.2016.02.023
Schulz, P., & Hede, V. (2018). Alternative and complementary approaches in psychiatry: Beliefs versus evidence. Dialogues in Clinical Neuroscience, 20(3), 207–214. PubMed ID: 30581290 doi:10.31887/DCNS.2018.20.3/pschulz
Scott, M.J. (2018). Improving Access to Psychological Therapies (IAPT): The need for radical reform. Journal of Health Psychology, 23(9), 1136–1147. PubMed ID: 29390891 doi:10.1177/1359105318755264
Scottish Intercollegiate Guidelines Network. (2010). Non-pharmaceutical management of depression in adults: A national clinical guideline. Edinburgh, UK: Scottish Intercollegiate Guidelines Network.
Searle, A., Calnan, M., Lewis, G., Campbell, J., Taylor, A., & Turner, K. (2011). Patients’ views of physical activity as treatment for depression: A qualitative study. British Journal of General Practice, 61(585), e149–e156. PubMed ID: 21439172 doi:10.3399/bjgp11X567054
Searle, A., Calnan, M., Turner, K.M., Lawlor, D.A., Campbell, J., Chalder, M., & Lewis, G. (2012). General practitioners’ beliefs about physical activity for managing depression in primary care. Mental Health and Physical Activity, 5(1), 13–19. doi:10.1016/j.mhpa.2011.11.001
Shaw, E.J., Sutcliffe, D., Lacey, T., & Stokes, T. (2013). Assessing depression severity using the UK Quality and Outcomes Framework depression indicators: A systematic review. British Journal of General Practice, 63(610), e309–e317. PubMed ID: 23643228 doi:10.3399/bjgp13X667169
Shern, D.L., & Moran, H. (2009). STAR*D: Helping to close the gap between science and practice. Psychiatric Services, 60(11), 1458–1459. PubMed ID: 19880460 doi:10.1176/ps.2009.60.11.1458
Smith, O.R.F., Knapstad, M., Alves, D.E., & Aarø, L.E. (2017). Initial results of prompt mental health care, the Norwegian version of improving access to psychological therapies. Psychotherapy and Psychosomatics, 86(6), 382–384. PubMed ID: 29131045 doi:10.1159/000477668
Smithson, J., & Mitchell, P.B. (2019). Antidepressants. Side Effects of Drugs Annual, 41, 13–26. doi:10.1016/bs.seda.2019.10.002
Spijker, J., Bockting, C.L.H., Meeuwissen, J.A.C., van Vliet, I.M., Emmelkamp, P.M.G., Hermens, M.L.M., & Balkom, A.L.J.M. (2013). Multidisciplinary guideline for depression: Guideline for the diagnosis, treatment, and counseling of adult patients with major depressive disorder (3rd revision). Utrecht, the Netherlands: Trimbos Instituut.
Stanton, R., Franck, C., Reaburn, P., & Happell, B. (2015). A pilot study of the views of general practitioners regarding exercise for the treatment of depression. Perspectives in Psychiatric Care, 51(4), 253–259. PubMed ID: 25307254 doi:10.1111/ppc.12088
Stanton, R., Rebar, A., & Rosenbaum, S. (2019). Exercise and mental health literacy in an Australian adult population. Depression and Anxiety, 36(5), 465–472. PubMed ID: 30328662 doi:10.1002/da.22851
Steen, S. (2020). A cost–benefit analysis of the Improving Access to Psychological Therapies programme using its key defining outcomes. Journal of Health Psychology, 25(13-14), 2487–2498. PubMed ID: 30284915 doi:10.1177/1359105318803751
Stoll, M., Mancini, A., Hubenschmid, L., Dreimüller, N., König, J., Cuijpers, P., … Lieb, K. (2020). Discrepancies from registered protocols and spin occurred frequently in randomized psychotherapy trials: A meta-epidemiologic study. Journal of Clinical Epidemiology, 128, 49–56. PubMed ID: 32828837 doi:10.1016/j.jclinepi.2020.08.013
Stubbs, B., Vancampfort, D., Hallgren, M., Firth, J., Veronese, N., Solmi, M., … Kahl, K.G. (2018). EPA guidance on physical activity as a treatment for severe mental illness: A meta-review of the evidence and position statement from the European Psychiatric Association (EPA), supported by the International Organization of Physical Therapists in Mental Health (IOPTMH). European Psychiatry, 54, 124–144. PubMed ID: 30257806 doi:10.1016/j.eurpsy.2018.07.004
Thase, M.E. (2011). The small specific effects of antidepressants in clinical trials: What do they mean to psychiatrists? Current Psychiatry Reports, 13(6), 476–482. PubMed ID: 21964929 doi:10.1007/s11920-011-0235-x
Trilk, J.L., & Phillips, E.M. (2014). Incorporating ‘Exercise is Medicine’ into the University of South Carolina School of Medicine Greenville and Greenville Health System. British Journal of Sports Medicine, 48(3), 165–167. PubMed ID: 24311603 doi:10.1136/bjsports-2013-093157
Trivedi, M.H., Rush, A.J., Wisniewski, S.R., Nierenberg, A.A., Warden, D., Ritz, L., … Fava, M. (2006). Evaluation of outcomes with citalopram for depression using measurement-based care in STAR*D: Implications for clinical practice. American Journal of Psychiatry, 163(1), 28–40. PubMed ID: 16390886 doi:10.1176/appi.ajp.163.1.28
Turner, E.H., Matthews, A.M., Linardatos, E., Tell, R.A., & Rosenthal, R. (2008). Selective publication of antidepressant trials and its influence on apparent efficacy. New England Journal of Medicine, 358(3), 252–260. PubMed ID: 18199864 doi:10.1056/NEJMsa065779
Vaccarino, V., Badimon, L., Bremner, J.D., Cenko, E., Cubedo, J., Dorobantu, M., … Bugiardini, R. (2020). Depression and coronary heart disease: 2018 position paper of the ESC working group on coronary pathophysiology and microcirculation. European Heart Journal, 41(17), 1687–1696. PubMed ID: 30698764 doi:10.1093/eurheartj/ehy913
Vuori, I.M., Lavie, C.J., & Blair, S.N. (2013). Physical activity promotion in the health care system. Mayo Clinic Proceedings, 88(12), 1446–1461. doi:10.1016/j.mayocp.2013.08.020
Wade, M., Mann, S., Copeland, R.J., & Steele, J. (2020). Effect of exercise referral schemes upon health and well-being: Initial observational insights using individual patient data meta-analysis from the National Referral Database. Journal of Epidemiology and Community Health, 74(1), 32–41. PubMed ID: 31740446 doi:10.1136/jech-2019-212674
Walker, E.R., McGee, R.E., & Druss, B.G. (2015). Mortality in mental disorders and global disease burden implications: A systematic review and meta-analysis. JAMA Psychiatry, 72(4), 334–341. PubMed ID: 25671328 doi:10.1001/jamapsychiatry.2014.2502
White, J., & Bero, L.A. (2010). Corporate manipulation of research: Strategies are similar across five industries. Stanford Law and Policy Review, 21(1), 105–134.
Wiles, N., Thomas, L., Abel, A., Ridgway, N., Turner, N., Campbell, J., … Lewis, G. (2013). Cognitive behavioural therapy as an adjunct to pharmacotherapy for primary care-based patients with treatment resistant depression: Results of the CoBalT randomised controlled trial. The Lancet, 381(9864), 375–384. PubMed ID: 23219570 doi:10.1016/S0140-6736(12)61552-9
Wiles, N.J., Thomas, L., Turner, N., Garfield, K., Kounali, D., Campbell, J., … Hollinghurst, S. (2016). Long-term effectiveness and cost-effectiveness of cognitive behavioural therapy as an adjunct to pharmacotherapy for treatment-resistant depression in primary care: Follow-up of the CoBalT randomised controlled trial. Lancet Psychiatry, 3(2), 137–144. PubMed ID: 26777773 doi:10.1016/S2215-0366(15)00495-2
Williams, C., Wilson, P., Morrison, J., McMahon, A., Walker, A., Allan, L., … Tansey, L. (2013). Guided self-help cognitive behavioural therapy for depression in primary care: A randomised controlled trial. PLoS One, 8(1), e52735. PubMed ID: 23326352 doi:10.1371/journal.pone.0052735
Williams, C.H. (2015). Improving access to psychological therapies (IAPT) and treatment outcomes: Epistemological assumptions and controversies. Journal of Psychiatric and Mental Health Nursing, 22(5), 344–351. PubMed ID: 26014832 doi:10.1111/jpm.12181
Yavchitz, A., Boutron, I., Bafeta, A., Marroun, I., Charles, P., Mantz, J., & Ravaud, P. (2012). Misrepresentation of randomized controlled trials in press releases and news coverage: A cohort study. PLoS Medicine, 9(9), e1001308. PubMed ID: 22984354 doi:10.1371/journal.pmed.1001308
Zhong, W., Kremers, H.M., Yawn, B.P., Bobo, W.V., St Sauver, J.L., Ebbert, J.O., … Rocca, W.A. (2014). Time trends of antidepressant drug prescriptions in men versus women in a geographically defined US population. Archives of Women’s Mental Health, 17(6), 485–492. PubMed ID: 25113318 doi:10.1007/s00737-014-0450-7
Zhong, W., Maradit-Kremers, H., St Sauver, J.L., Yawn, B.P., Ebbert, J.O., Roger, V.L., … Rocca, W.A. (2013). Age and sex patterns of drug prescribing in a defined American population. Mayo Clinic Proceedings, 88(7), 697–707. doi:10.1016/j.mayocp.2013.04.021
Zwald, M.L., Kit, B.K., Fakhouri, T., Hughes, J.P., & Akinbami, L.J. (2019). Prevalence and correlates of receiving medical advice to increase physical activity in U.S. adults: National Health and Nutrition Examination Survey 2013–2016. American Journal of Preventive Medicine, 56(6), 834–843. PubMed ID: 31003809 doi:10.1016/j.amepre.2019.01.003
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